The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing
Author
Dopfer, Elaine P.; Hartl, Frederike A.; Oberg, Hans-Heinrich; Siegers, Gabrielle M.; Yousefi, O. Sascha; Kock, Sylvia; Fiala, Gina J.; Garcillán, Beatriz; Sandstrom, Andrew; Alarcón, Balbino; Regueiro, José R.; Kabelitz, Dieter; Adams, Erin J.; Minguet, Susana; Wesch, Daniela; Fisch, Paul; Schamel, Wolfgang W.A.Entity
UAM. Departamento de Biología MolecularPublisher
Cell PressDate
2014-06-12Citation
10.1016/j.celrep.2014.04.049
Cell Reports 7.5 (2014): 1704-1715
ISSN
2211-1247DOI
10.1016/j.celrep.2014.04.049Funded by
This work was supported by the German Research Foundation (DFG) through grants SFB620 to W.W.A.S. and P.F., SCHA976/2-1 to W.W.A.S., the Excellence Initiatives GSC-4 (Spemann Graduate School), EXC294 (BIOSS) to G.J.F and W.W.A.S., EXC306 (Inflammation-at-Interfaces) to D.K., the Pancreatic Cancer Consortium Kiel (WE 3559/2-1) to D.W. and D.K., the EU through grant FP7/2007-2013 (SYBILLA) to W.W.A.S., E.P.D., and B.A., the Innovationfonds Forschung-2012 grant to F.A.H. and S.M., MEC (SAF2011-24235) to B.G., and the Fundacion Ramon Areces to B.A.Project
Comunidad de Madrid. S2010/BMD-2332/INDISNET; info:eu-repo/grantAgreement/EC/FP7/201106Editor's Version
http://dx.doi.org/10.1016/j.celrep.2014.04.049Subjects
Combinatorial code; Drosophila; FMRFa; Neuropeptidergic cell identity; Temporal genes; Terminal differentiation; Biología y Biomedicina / BiologíaRights
© 2014 The authorsAbstract
Activation of the T cell receptor (TCR) by antigen is
the key step in adaptive immunity. In the abTCR,
antigen induces a conformational change at the
CD3 subunits (CD3 CC) that is absolutely required
for abTCR activation. Here, we demonstrate that
the CD3 CC is not induced by antigen stimulation of
the mouse G8 or the human Vg9Vd2 gdTCR. We
find that there is a fundamental difference between
the activation mechanisms of the abTCR and gdTCR
that map to the constant regions of the TCRab/gd
heterodimers. Enforced induction of CD3 CC with a
less commonly used monoclonal anti-CD3 promoted
proximal gdTCR signaling but inhibited cytokine
secretion. Utilizing this knowledge, we could dramatically
improve in vitro tumor cell lysis by activated
human gd T cells. Thus, manipulation of the CD3
CC might be exploited to improve clinical gd T cellbased
immunotherapies.
Files in this item
Google Scholar:Dopfer, Elaine P.
-
Hartl, Frederike A.
-
Oberg, Hans-Heinrich
-
Siegers, Gabrielle M.
-
Yousefi, O. Sascha
-
Kock, Sylvia
-
Fiala, Gina J.
-
Garcillán, Beatriz
-
Sandstrom, Andrew
-
Alarcón, Balbino
-
Regueiro, José R.
-
Kabelitz, Dieter
-
Adams, Erin J.
-
Minguet, Susana
-
Wesch, Daniela
-
Fisch, Paul
-
Schamel, Wolfgang W.A.
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
TCR nanoclusters as the framework for transmission of conformational changes and cooperativity
Blanco, Raquel; Alarcón, Balbino
2012 -
Scaled momentum distributions for K S 0 and ∧/∧ in DIS at HERA
Abramowicz, Halina; Abt, Iris; Adamczyk, Leszek; Adamus, Marek; Aggarwal, Ritu; Antonelli, Stefano; Antonioli, Pietro; Antonov, Alexei A.; Arneodo, Michele; Aushev, Volodymyr E.; Aushev, Y.; Bachynska, O.; Bamberger, Andreas; Barakbaev, A. N.; Barbagli, G.; Bári, Gergely; Barreiro Alonso, Fernando; Bartosik, N.; Bartsch, D.; Basile, Maurizio; Behnke, Olaf; Behr, Jörg; Behrens, Ulf; Bellagamba, Lorenzo; Bertolin, Alessandro; Bhadra, Sampa; Bindi, Marcello; Blohm, C.; Bokhonov, V.; Bołd, Tomasz; Bondarenko, K.; Boos, E. G.; Borras, Kerstin; Boscherini, Davide; Bot, D.; Brock, Ian C.; Brownson, Eric; Brugnera, Riccardo; Brümmer, Nichol C.; Bruni, Alessia; Bruni, Graziano; Brzozowska, Beata; Bussey, Peter J.; Bylsma, B. G.; Caldwell, Allen C.; Capua, M.; Carlin, Roberto; Catterall, C. D.; Chekanov, S. V.; Chwastowski, Janusz J.; Ciborowski, Jacek; Ciesielski, Robert; Cifarelli, Luisa; Cindolo, Federico; Contin, Andrea; Cooper-Sarkar, Amanda M.; Coppola, Nicola; Corradi, Massimo; Corriveau, François; Costa, Mario J.; D'Agostini, Giulio; Dal Corso, Flavio; Peso Malagón, José del; Dementiev, R. K.; De Pasquale, Salvatore; Derrick, Mark; Devenish, Robin C E; Dobur, Didar; Dolgoshein, Boris A.; Dolinska, Ganna; Doyle, Anthony T.; Drugakov, V.; Durkin, Louis S.; Dusini, S.; Eisenberg, Yehuda; Ermolov., P. F.; Eskreys, A. W.; Fang, Shuangshi; Fazio, Salvatore; Ferrando, James; Ferrero, Mauro I.; Figiel, Jan; Forrest, Matthew; Foster, Brian; Gach, Grzegorz P.; Galas, Anna I.; Gallo, Elisabetta; Garfagnini, Alberto; Geiser, Achim; Gialas, Ioannis; Gladilin, Leonid K.; Gladkov, Daniil; Glasman Kuguel, Claudia Beatriz; Gogota, O.; Golubkov, Yu A.; Göttlicher, Peter; Grabowska-Bo, I.; Grebenyuk, Julia; Gregor, Ingrid Maria; Grigorescu, Gabriela; Grzelak, Grzegorz; Gueta, O.; Guzik, M.; Gwenlan, Claire; Haas, Tobias; Hain, W.; Hamatsu, Ryosuke; Hart, John C.; Hartmann, Hans Jörg; Hartner, G.; Hilger, Erwin; Hochman, Don; Hori, R.; Horton, K.; Hüttmann, Antje; Ibrahim, Zainol Abidin; Iga, Yasunobu; Ingbir, Ronen; Ishitsuka, Masaki; Jakob, H. P.; Januschek, Friederike; Jones, T. W.; Jüngst, M.; Kadenko, Igor M.; Kahle, Benjamin; Kananov, S.; Kanno, Takayuki; Karshon, Uri; Karstens, Falk; Katkov, Igor I.; Kaur, Manjit; Kaur, Prabhdeep; Keramidas, Avraam A.; Khein, Lev A.; Kim, Jihyun; Kisielewska, Danuta; Kitamura, Shoichi; Klanner, Robert; Klein, Uta; Koffeman, Els N.; Kooijman, Paul M.; Korol; Korzhavina, Irina A.; Kotański, A.; Kötz, Ulrich; Kowalski, Henryk; Kuprash, Oleg E.; Kuze, Masahiro; Lee, Albert; Levchenko, Boris B.; Levy, Aharon; Libov, Vladyslav; Limentani, Sylvia; Ling, T. Y.; Lisovyi, Mykhailo; Łobodzińska, Ewelina Maria; Lohmann, Wolfgang; Löhr, Bernd; Lohrmann, Erich; Long, Kenneth; Longhin, Andrea; Lontkovskyi, Denys I.; Lukina, Ou Yu; Maeda, Jouji; Magill, Stephen R.; Makarenko, Irina V.; Malka, Janusz; Mankel, Rainer; Margotti, Anselmo; Marini, Giuseppe P.; Martin, John F.; Mastroberardino, A.; Mattingly, M. C K; Melzer-Pellmann, Isabell Alissandra; Mergelmeyer, Sebastian; Miglioranzi, Silvia; Mohamad Idris, F.; Monaco, Vincenzo; Montanari, Andrea; Morris, John D.; Mujkic, Kenan; Musgrave, B.; Nagano, Kunihiro; Namsoo, Tim A.; Nania, Rosario; Nigro, Andrea; Ning, Y.; Nobe, Takuya; Noor, U.; Notz, Dieter; Nowak, Roman J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, Noriaki; Oliver, Katie; Olkiewicz, Krystyna; Onishchuk, Yu M.; Papageorgiu, K.; Parenti, Andrea; Paul, Ewald; Pawlak, J. M.; Pawlik, Barbara; Pelfer, Pier Giovanni; Pellegrino, Antonio R.; Perlański, Wojciech; Perrey, Hanno; Piotrzkowski, Krzysztof; Pluciński, Pawel; Pokrovskiy, N. S.; Polini, Alessandro; Proskuryakov, Alexander S.; Przybycień, Mariusz B.; Raval, Amita; Reeder, D. D.; Reisert, Burkard; Ren, Zhongliang; Repond, José; Ri, Y. D.; Robertson, Ashley I.; Roloff, Philipp; Rubinsky, I. A.; Ruspa, Marta; Sacchi, Roberto; Salii, Andrii; Samson, Ursula; Sartorelli, Gabriella; Savin, Alexander A.; Saxon, David H.; Schioppa, Marco; Schlenstedt, Stefan; Schleper, Peter; Schmidke, William B.; Schneekloth, U.; Schönberg, Verena; Schörner-Sadenius, Thomas; Schwartz, Joshua David; Sciulli, Frank J.; Shcheglova, Lydia M.; Shehzadi, R.; Shimizu, Shima; Singh, Inderpal J.; Skillicorn, Ian O.; Słomiński, Wojciech; Smith, Wesley H.; Sola, Valentina; Solano, Ada; Son, Dongchul; Sosnovtsev, V. V.; Spiridonov, A.; Stadie, Hartmut; Stanco, Luca; Stern, Amir; Stewart, T. P.; Stifutkin, A. A.; Stopa, P.; Suchkov, S. I.; Susinno, G. C.; Suszycki, Leszek; Sztuk-Dambietz, Jolanta; Szuba, Dorota; Szuba, J.; Tapper, A. D.; Tassi, Enrico; Terrón Cuadrado, Juan; Theedt, T.; Tiecke., H. G J M; Tokushuku, Katsuo; Tomalak, O.; Tomaszewska, Justyna; Tsurugai, Takashi; Turcato, Monica; Tymieniecka, Teresa; Vázquez., Manuel M.; Verbytskyi, Andrii; Viazlo, O.; Vlasov, Nikolai N.; Volynets, G. V.; Walczak, Roman; Wan Abdullah, Wan Ahmad Tajuddin Bin; Whitmore, J. J.; Wiggers, Lisbeth W.; Wing, Matthew; Własenko, Michał; Wolf, Günter K.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, Satoru; Yamazaki, Yasunori; Yoshida, Rik; Youngman, Christopher; Zarnecki, Aleksander Filip; Zawiejski, Leszek; Zenaiev, Oleksandr; Zeuner, Wolfram D.; Zhautykov, B. O.; Zhmak, N.; Zhou, C.; Zichichi, Antonino; Zolkapli, Zukhaimira; Zolko, M.; Zotkin, D. S.
2012-03-07 -
Study of tau-pair production at HERA
Levy, Aharon; Abramowicz, Halina; Adamczyk, Leszek; Adamus, Marek; Aggarwal, Ritu; Antonelli, Stefano; Antonioli, Pietro; Antonov, Alexei A.; Arneodo, Michele; Aushev, Volodymyr E.; Aushev, Y.; Bachynska, O.; Bamberger, Andreas; Barakbaev, A. N.; Barbagli, G.; Bári, Gergely; Barreiro Alonso, Fernando; Bartosik, N.; Bartsch, D.; Basile, Maurizio; Behnke, Olaf; Behr, Jörg; Behrens, Ulf; Bellagamba, Lorenzo; Bertolin, Alessandro; Bhadra, Sampa; Bindi, Marcello; Blohm, C.; Bokhonov, V.; Bołd, Tomasz; Bolilyi, O.; Boos, E. G.; Borras, Kerstin; Boscherini, Davide; Bot, D.; Boutle, Sarah K.; Brock, Ian C.; Brownson, Eric; Brugnera, Riccardo; Brümmer, Nichol C.; Bruni, Alessia; Bruni, Graziano; Brzozowska, Beata; Bussey, Peter J.; Butterworth, Jonathan M.; Bylsma, B. G.; Caldwell, Allen C.; Capua, M.; Carlin, Roberto; Catterall, C. D.; Chekanov, S. V.; Chwastowski, Janusz J.; Ciborowski, Jacek; Ciesielski, Robert; Cifarelli, Luisa; Cindolo, Federico; Contin, Andrea; Cooper-Sarkar, Amanda M.; Coppola, Nicola; Corradi, Massimo; Corriveau, François; Costa, Michele J.; D'Agostini, Giulio; Dal Corso, Flavio; Peso Malagón, José del; Dementiev, R. K.; De Pasquale, Salvatore; Derrick, Mark; Devenish, Robin C E; Dobur, Didar; Dolgoshein, Boris A.; Dolinska, Ganna; Doyle, Anthony T.; Drugakov, V.; Durkin, Louis S.; Dusini, S.; Eisenberg, Yehuda; Ermolov., P. F.; Eskreys, A. W.; Fang, Shuangshi; Fazio, Salvatore; Ferrando, James; Ferrero, Mauro I.; Figiel, Jan; Forrest, Matthew; Foster, Brian; Fourletov, S.; Gach, Grzegorz P.; Galas, Anna I.; Gallo, Elisabetta; Garfagnini, Alberto; Geiser, Achim; Gialas, Ioannis; Gladilin, Leonid K.; Gladkov, Daniil; Glasman Kuguel, Claudia Beatriz; Gogota, O.; Golubkov, Yu A.; Göttlicher, Peter; Grabowska-Bołd, Iwona; Grebenyuk, Julia; Gregor, Ingrid Maria; Grigorescu, Gabriela; Grzelak, Grzegorz; Gueta, O.; Gwenlan, Claire; Haas, Tobias; Hain, W.; Hamatsu, Ryosuke; Hart, John C.; Hartmann, Hans Jörg; Hartner, G.; Hilger, Erwin; Hochman, Don; Hori, R.; Horton, K.; Hüttmann, Antje; Iacobucci, Giuseppe; Ibrahim, Zainol Abidin; Iga, Yasunobu; Ingbir, Ronen; Ishitsuka, Masaki; Jakob, H. P.; Januschek, Friederike; Jiménez, Marcos J López; Jones, T. W.; Jüngst, M.; Kadenko, Igor M.; Kahle, Benjamin; Kamaluddin, B.; Kananov, S.; Kanno, Takayuki; Karshon, Uri; Karstens, Falk; Katkov, Igor I.; Kaur, Manjit; Kaur, Prabhdeep; Keramidas, Avraam A.; Khein, Lev A.; Kim, Jihyun; Kisielewska, Danuta; Kitamura, Shoichi; Klanner, Robert; Klein, Uta; Koffeman, Els N.; Kooijman, Paul M.; Korol, Ie E.; Korzhavina, Irina A.; Kotański, A.; Kötz, Ulrich; Kowalski, Henryk; Kulinski, P.; Kuprash, Oleg E.; Kuze, Masahiro; Lee, Albert; Levchenko, Boris B.; Libov, Vladyslav; Limentani, Sylvia; Ling, T. Y.; Lisovyi, Mykhailo; Łobodzińska, Ewelina Maria; Lohmann, Wolfgang; Löhr, Bernd; Lohrmann, Erich; Loizides, J. H.; Long, Kenneth; Longhin, Andrea; Lontkovskyi, Denys I.; Lukina, Ou Yu; Łuz, P.; Maeda, Jouji; Magill, Stephen R.; Makarenko, Irina V.; Malka, Janusz; Mankel, Rainer; Margotti, Anselmo; Marini, Giuseppe P.; Martin, John F.; Mastroberardino, A.; Mattingly, M. C K; Melzer-Pellmann, Isabell Alissandra; Mergelmeyer, Sebastian; Miglioranzi, Silvia; Mohamad Idris, F.; Monaco, Vincenzo; Montanari, Andrea; Morris, John D.; Mujkic, Kenan; Musgrave, B.; Nagano, Kunihiro; Namsoo, Tim A.; Nania, Rosario; Nicholass, Dan; Nigro, Andrea; Ning, Y.; Noor, U.; Notz, Dieter; Nowak, Roman J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, Noriaki; Oliver, Katie; Olkiewicz, Krystyna; Onishchuk, Yu M.; Papageorgiu, K.; Parenti, Andrea; Paul, Ewald; Pawlak, J. M.; Pawlik, Barbara; Pelfer, Pier Giovanni; Pellegrino, Antonio R.; Perlański, Wojciech; Perrey, Hanno; Piotrzkowski, Krzysztof; Pluciński, Pawel; Pokrovskiy, N. S.; Polini, Alessandro; Proskuryakov, Alexander S.; Przybycień, Mariusz B.; Raval, Amita; Reeder, D. D.; Reisert, Burkard; Ren, Zhongliang; Repond, José; Ri, Y. D.; Robertson, Ashley I.; Roloff, Philipp; Ron Álvarez, Elías; Rubinsky, I. A.; Ruspa, Marta; Sacchi, Roberto; Salii, Andrii; Samson, Ursula; Sartorelli, Gabriella; Savin, Alexander A.; Saxon, David H.; Schioppa, Marco; Schlenstedt, Stefan; Schleper, Peter; Schmidke, William B.; Schneekloth, U.; Schönberg, Verena; Schörner-Sadenius, Thomas; Schwartz, Joshua David; Sciulli, Frank J.; Shcheglova, Lydia M.; Shehzadi, R.; Shimizu, Shima; Singh, Inderpal J.; Skillicorn, Ian O.; Słomiński, Wojciech; Smith, Wesley H.; Sola, Valentina; Solano, Ada; Son, Dongchul; Sosnovtsev, V. V.; Spiridonov, A.; Stadie, Hartmut; Stanco, Luca; Stern, Amir; Stewart, T. P.; Stifutkin, A. A.; Stopa, P.; Suchkov, S. I.; Susinno, G. C.; Suszycki, Leszek; Sztuk-Dambietz, Jolanta; Szuba, Dorota; Szuba, J.; Tapper, A. D.; Tassi, Enrico; Terrón Cuadrado, Juan; Theedt, T.; Tiecke., H. G J M; Tokushuku, Katsuo; Tomalak, O.; Tomaszewska, Justyna; Tsurugai, Takashi; Turcato, Monica; Tymieniecka, Teresa; Uribe- Estrada, C.; Vázquez., Manuel M.; Verbytskyi, Andrii; Viazlo, O.; Vlasov, Nikolai N.; Volynets, G. V.; Walczak, Roman; Wan Abdullah, Wan Ahmad Tajuddin Bin; Whitmore, James J.; Whyte, Jerome; Wiggers, Lisbeth W.; Wing, Matthew; Własenko, Michał; Wolf, Günter K.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, Satoru; Yamazaki, Yasunori; Yoshida, Rik; Youngman, Christopher; Zarnecki, Aleksander Filip; Zawiejski, Leszek; Zenaiev, Oleksandr; Zeuner, Wolfram D.; Zhautykov, B. O.; Zhmak, N.; Zhou, C.; Zichichi, Antonino; Zolko, M.; Zotkin, D. S.; Zulkapli, Zulidza
2011-02-28