Antiviral compounds obtained from microalgae commonly used as carotenoid sources

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dc.contributor.author Santoyo, Susana
dc.contributor.author Jaime, Laura
dc.contributor.author Plaza, Merichel
dc.contributor.author Herrero, Miguel
dc.contributor.author Rodriguez-Meizoso, Irene
dc.contributor.author Ibañez, Elena
dc.contributor.author Reglero, Guillermo
dc.contributor.other UAM. Departamento de Química Física Aplicada es_ES
dc.date.accessioned 2014-07-04T11:25:43Z
dc.date.available 2014-07-04T11:25:43Z
dc.date.issued 2012-08-01
dc.identifier.citation Journal of Applied Phycology 24.4 (2012): 731–741 en_US
dc.identifier.issn 0921-8971 (print) es_ES
dc.identifier.issn 1573-5176 (online) es_ES
dc.identifier.uri http://hdl.handle.net/10486/660718
dc.description The final publication is available at Springer via http://dx.doi.org/10.1007/s10811-011-9692-1 en_US
dc.description.abstract Pressurized liquid extraction (PLE), an environmentally friendly technique, has been used to obtain antiviral compounds from microalgae commonly used as carotenoids sources: Haematococcus pluvialis and Dunaliella salina. The antiviral properties of PLE extracts (hexane, ethanol and water) were evaluated against herpes simplex virus type 1 (HSV-1) at different stages during viral infection. Pre-treatment of Vero cells with 75 µg mL-1 of H. pluvialis ethanol extract inhibited virus infection by approx. 85%, whereas the same concentration of water and hexane extracts reduced the virus infectivity 75% and 50% respectively. D. salina extracts were less effective than H. pluvialis extracts and presented a different behaviour, since water and ethanol extracts produced a similar virus inhibition (65%). Moreover, H. pluvialis ethanol extract was also the most effective against HSV-1 intracellular replication. The antiviral activity of water PLE extracts was found to correlate with polysaccharides, since the polysaccharide-rich fraction isolated from these extracts showed higher antiviral activity than the original water extracts. A GC-MS characterization of the H. pluvialis ethanol extract showed the antiviral activity of this extract could be partially related with the presence of short chain fatty acids, although other compounds could be involved in this activity; meanwhile, in the case of D. salina ethanol extract other compounds seemed to be implied, such as: β-ionone, neophytadiene, phytol, palmitic acid and α-linolenic acid. Results demonstrated the use of PLE allows obtaining antiviral compounds from microalgae used as carotenoids sources, which gives both microalgae biomass an added value. en_US
dc.description.sponsorship This work has been financed by the Spanish Ministry of Education and Science (AGL2005-06726-C04), the programme CONSOLIDER-INGENIO 2010 (CDS2007-00063) and the regional programme ALIBIRD-CM S-0505/AGR-0153 from the Comunidad de Madrid, Spain. en_US
dc.format.extent 11 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso eng en
dc.publisher Springer Verlag en_US
dc.relation.ispartof Journal of Applied Phycology en_US
dc.rights © Springer Science+Business Media B.V. 2011 en_US
dc.subject.other Antiviral activity en_US
dc.subject.other Microalgae en_US
dc.subject.other Dunaliella salina es_ES
dc.subject.other Haematococcus pluvialis es_ES
dc.subject.other Pressurized liquid extraction en_US
dc.title Antiviral compounds obtained from microalgae commonly used as carotenoid sources en_US
dc.type article en_US
dc.subject.eciencia Química es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s10811-011-9692-1 en_US
dc.identifier.doi 10.1007/s10811-011-9692-1 es_ES
dc.identifier.publicationfirstpage 731 es_ES
dc.identifier.publicationissue 4 es_ES
dc.identifier.publicationlastpage 741 es_ES
dc.identifier.publicationvolume 24 es_ES
dc.relation.projectID Comunidad de Madrid. S2009/AGR-1469/ALIBIRD es_ES
dc.type.version info:eu-repo/semantics/acceptedVersion en_US
dc.rights.accessRights openAccess en
dc.authorUAM Herrero Calleja, Miguel (264301)


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