Antiviral activities of Boletus edulis, Pleurotus ostreatus and Lentinus edodes extracts and polysaccharide fractions against Herpes simplex virus type 1

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dc.contributor.author Santoyo, Susana
dc.contributor.author Ramírez-Anguiano, Ana Cristina
dc.contributor.author Aldars-García, Laila
dc.contributor.author Reglero, Guillermo
dc.contributor.author Soler-Rivas, Cristina
dc.contributor.other UAM. Departamento de Química Física Aplicada es_ES
dc.date.accessioned 2014-07-18T11:50:04Z
dc.date.available 2014-07-18T11:50:04Z
dc.date.issued 2012-11
dc.identifier.citation Journal of Food and Nutrition Research 51. 4 (2012): 225-235 en_US
dc.identifier.issn 1336-8672 es_ES
dc.identifier.uri http://hdl.handle.net/10486/660904
dc.description Deposited with permission en_US
dc.description.abstract Antiviral properties of water and methanol extracts from Lentinus edodes, Boletus edulis and Pleurotus ostreatus were evaluated against herpes simplex virus type 1 (HSV-1). Pre-treatment of Vero cells with 75 mg·ml-1 water extracts before virus addition, inhibited 60% of the virus infection and its addition during the virus adsorption period inhibited it up to 80%. Moreover, the mushrooms water extracts were able to significantly inhibit the in vitro virus replication, showing the concentration of a substance required to reduce plaque number in Vero cells by 50% (IC50) values from 26.69 mg·ml-1 to 35.12 mg·ml-1. Methanol extracts exhibited a lower antiviral activity in all cases. In order to identify the type of compounds responsible for the antiviral activity, the low molecular weight (LMW) and high molecular weight (HMW) fractions were evaluated. The activity was found to correlate with the β-glucans present in the polysaccharide fractions, which showed higher antiviral activity than the complete water extracts except for B. edulis where other compounds (probably chitin-binding lectins) might have contributed to the observed activity. en_US
dc.description.sponsorship This work was also supported by the ALIBIRD-CM S2009/AGR-1469 regional program from the Comunidad de Madrid (Spain) en_US
dc.format.extent 11 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Výskumný ústav potravinársky NPPC (Food Research Institute NPPC) en_US
dc.relation.ispartof Journal of Food and Nutrition Research en_US
dc.rights Copyright © 2012 VUP Food Research Institute, Bratislava en_US
dc.subject.other Edible mushroom en_US
dc.subject.other Antiviral activity en_US
dc.subject.other Herpes simplex virus type 1 en_US
dc.subject.other Water extract en_US
dc.subject.other Methanol extract en_US
dc.subject.other Chitin en_US
dc.subject.other β-glucan en_US
dc.title Antiviral activities of Boletus edulis, Pleurotus ostreatus and Lentinus edodes extracts and polysaccharide fractions against Herpes simplex virus type 1 en_US
dc.type article en
dc.subject.eciencia Química es_ES
dc.identifier.publicationfirstpage 225 es_ES
dc.identifier.publicationissue 4 es_ES
dc.identifier.publicationlastpage 235 es_ES
dc.identifier.publicationvolume 51 es_ES
dc.relation.projectID Comunidad de Madrid. S2009/AGR-1469/ALIBIRD es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en


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