Antiviral properties of supercritical CO2 extracts from oregano and sage

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dc.contributor.author Santoyo, Susana
dc.contributor.author Jaime, Laura
dc.contributor.author García-Risco, Mónica R.
dc.contributor.author Ruiz-Rodríguez, Alejandro
dc.contributor.author Reglero, Guillermo
dc.contributor.other UAM. Departamento de Química Física Aplicada es_ES
dc.date.accessioned 2014-10-17T10:23:45Z
dc.date.available 2014-10-17T10:23:45Z
dc.date.issued 2014-05-28
dc.identifier.citation International Journal of Food Properties 17 (2014): 1150-1161 en_US
dc.identifier.issn 1094-2912 (print) es_ES
dc.identifier.issn 1532-2386 (online) es_ES
dc.identifier.uri http://hdl.handle.net/10486/662158
dc.description This is an Author's Original Manuscript of an article published by Taylor & Francis Group in International Journal of Food Properties on 2014, may, 28, available online: http://www.tandfonline.com/doi/full/10.1080/10942912.2012.700539 en_US
dc.description.abstract The antiviral properties of supercritical CO2 extracts obtained from oregano and sage were evaluated against the herpes simplex virus type 1 at different stages during virus infection. All the extracts tested presented a moderate extracellular direct virucidal activity, although a pre-treatment of Vero cells with 10 μg/mL of sage extracts before virus addition inhibited 70% of the virus infection. Moreover, supercritical extracts of sage and oregano were able to significantly inhibit the in vitro virus replication, showing IC50 values of 1.88 and 5.33 μg/mL respectively. Carvacrol and thymol could be pointed out as the compounds responsible for the antiviral activity found in oregano supercritical extracts, meanwhile, borneol, camphor and 1,8-cineole could be proposed as antiviral compounds in supercritical sage extracts. Results demonstrated that supercritical extraction was an appropriate technique to obtain antiviral extracts from oregano and sage. en_US
dc.description.sponsorship This work has been supported by the program CONSOLIDER-INGENIO 2010 (CDS2007-00063) and the regional program ALIBIRD-CM S0505/AGR-0153 from the Comunidad de Madrid, Spain. en_US
dc.format.extent 28 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Taylor and Francis Group en_US
dc.relation.ispartof International Journal of Food Properties en_US
dc.rights © Taylor and Francis Group, LLC. en_US
dc.subject.other Antiviral activity en_US
dc.subject.other Herpes simplex virus type 1 en_US
dc.subject.other Oregano es_ES
dc.subject.other Sage en_US
dc.subject.other Supercritical fluid extraction es_ES
dc.title Antiviral properties of supercritical CO2 extracts from oregano and sage en_US
dc.type article en
dc.subject.eciencia Química es_ES
dc.date.embargoend 2015-05-29
dc.relation.publisherversion http://dx.doi.org/10.1080/10942912.2012.700539 es_ES
dc.identifier.doi 10.1080/10942912.2012.700539 es_ES
dc.identifier.publicationfirstpage 1150 es_ES
dc.identifier.publicationissue 5 es_ES
dc.identifier.publicationlastpage 1161 es_ES
dc.identifier.publicationvolume 17 es_ES
dc.relation.projectID Comunidad de Madrid. S2009/AGR-1469/ALIBIRD es_ES
dc.type.version info:eu-repo/semantics/acceptedVersion es_ES
dc.rights.accessRights openAccess en


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