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dc.contributor.authorDíaz-López, Antonio
dc.contributor.authorMoreno Bueno, Gema 
dc.contributor.authorCano, Amparo
dc.contributor.otherUAM. Departamento de Bioquímicaes_ES
dc.date.accessioned2014-10-27T13:07:43Z
dc.date.available2014-10-27T13:07:43Z
dc.date.issued2014-04-25
dc.identifier.citationCancer Management and Research 6.1 (2014): 205-216en_US
dc.identifier.issn1179-1322 (online)es_ES
dc.identifier.issn0190-0129 (print)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/662273
dc.description.abstractThe microRNAs (miRNAs) are a class of small, 20–22 nucleotides in length, endogenously expressed noncoding RNAs that regulate multiple targets posttranscriptionally. Interestingly, miRNAs have emerged as regulators of most physiological and pathological processes, including metastatic tumor progression, in part by controlling a reversible process called epithelial-to-mesenchymal transition (EMT). The activation of EMT increases the migratory and invasive properties fundamental for tumor cell spread while activation of the reverse mesenchymal-to-epithelial transition is required for metastasis outgrowth. The EMT triggering leads to the activation of a core of transcription factors (EMT-TFs) – SNAIL1/SNAIL2, bHLH (E47, E2-2, and TWIST1/TWIST2), and ZEB1/ZEB2 – that act as E-cadherin repressors and, ultimately, coordinate EMT. Recent evidence indicates that several miRNAs regulate the expression of EMT-TFs or EMT-activating signaling pathways. Interestingly, some miRNAs and EMT-TFs form tightly interconnected negative feedback loops that control epithelial cell plasticity, providing self-reinforcing signals and robustness to maintain the epithelial or mesenchymal cell status. Among the most significant feedback loops, we focus on the ZEB/miR-200 and the SNAIL1/miR-34 networks that hold a clear impact in the regulation of the epithelial-mesenchymal state. Recent insights into the p53 modulation of the EMT-TF/miRNA loops and epigenetic regulatory mechanisms in the context of metastasis dissemination will also be discussed. Understanding the regulation of EMT by miRNAs opens new avenues for the diagnosis and prognosis of tumors and identifies potential therapeutic targets that might help to negatively impact on metastasis dissemination and increasing patient survivalen_US
dc.description.sponsorshipAC is funded by grants of the Spanish Ministry of Economy and Competitiveness, formerly Innovation and Sciences, (SAF2010-21143; Consolider-Ingenio CSD2007-00017) and Association for International Cancer Research (grant 12-1057). GMB is funded by SAF2010-20175, AECC-2011 and Instituto de Salud Carlos III (ISCIII) PI13/00132. GMB and AC are funded by the Community of Madrid (S2010/BMD-2303) and the Instituto de Salud Carlos III (RETIC-RD12/0036/0007). ADL is a postdoctoral researcher funded by the Sara Borrell program (ISCIII).es_ES
dc.format.extent12 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherDove Medical Press Limiteden_US
dc.relation.ispartofCancer Management and Researchen_US
dc.rights© 2014 Díaz-López et al.en
dc.subject.otherCanceren_US
dc.subject.otherEMTen_US
dc.subject.otherMETen_US
dc.subject.otherMetastasisen_US
dc.subject.othermicroRNAsen_US
dc.titleRole of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectivesen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.2147/CMAR.S38156es_ES
dc.identifier.doi10.2147/CMAR.S38156es_ES
dc.identifier.publicationfirstpage205es_ES
dc.identifier.publicationissue1es_ES
dc.identifier.publicationlastpage216es_ES
dc.identifier.publicationvolume6es_ES
dc.relation.projectIDComunidad de Madrid. S2010/BMD-2303/RECAREes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimiento – NoComerciales_ES
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Medicina
dc.institutoUAMInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)


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