Nitrosothiols in the immune system: Signaling and protection
Entity
UAM. Departamento de Biología MolecularPublisher
Mary Ann Liebert, Inc.Date
2013-01-20Citation
10.1089/ars.2012.4765
Antioxidants and Redox Signaling 18.3 (2013): 288-308
ISSN
1523-0864 (print); 1557-7716 (online)DOI
10.1089/ars.2012.4765Funded by
Financed by the Spanish Government grants CSD2007-00020 (RosasNet, Consolider-Ingenio 2010 programme), CP07/00143 (Miguel Servet programme), and PS09/00101; and PI10/02136Editor's Version
http://dx.doi.org/10.1089/ars.2012.4765Subjects
MedicinaNote
Antioxidants and Redox Signaling 18.3 (2013): 288-308Rights
© 2013, Mary Ann Liebert, Inc.Abstract
Significance: In the immune system, nitric oxide (NO) has been mainly associated with antibacterial defenses exerted through oxidative, nitrosative, and nitrative stress and signal transduction through cyclic GMP-dependent mechanisms. However, S-nitrosylation is emerging as a post-translational modification (PTM) involved in NO-mediated cell signaling. Recent Advances: Precise roles for S-nitrosylation in signaling pathways have been described both for innate and adaptive immunity. Denitrosylation may protect macrophages from their own S-nitrosylation, while maintaining nitrosative stress compartmentalized in the phagosomes. Nitrosothiols have also been shown to be beneficial in experimental models of autoimmune diseases, mainly through their role in modulating T-cell differentiation and function. Critical Issues: Relationship between S-nitrosylation, other thiol redox PTMs, and other NO-signaling pathways has not been always taken into account, particularly in the context of immune responses. Methods for assaying S-nitrosylation in individual proteins and proteomic approaches to study the S-nitrosoproteome are constantly being improved, which helps to move this field forward. Future Directions: Integrated studies of signaling pathways in the immune system should consider whether S-nitrosylation/denitrosylation processes are among the PTMs influencing the activity of key signaling and adaptor proteins. Studies in pathophysiological scenarios will also be of interest to put these mechanisms into broader contexts. Interventions modulating nitrosothiol levels in autoimmune disease could be investigated with a view to developing new therapies
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Google Scholar:Hernansanz Agustín, Pablo
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Izquierdo-Álvarez, Alicia
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García-Ortiz, Almudena
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Ibiza, Sales
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Serrador, Juan Manuel
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Martínez-Ruíz, Antonio
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