dc.contributor.author | Chamorro, Pablo | |
dc.contributor.author | Muñiz, Carlos | |
dc.contributor.author | Levi, Rafael | |
dc.contributor.author | Arroyo, David | |
dc.contributor.author | Varona Martínez, Pablo | |
dc.contributor.author | Rodríguez Ortiz, Francisco Borja | |
dc.contributor.other | UAM. Departamento de Ingeniería Informática | es_ES |
dc.date.accessioned | 2014-11-21T19:00:19Z | |
dc.date.available | 2014-11-21T19:00:19Z | |
dc.date.issued | 2012-07-19 | |
dc.identifier.citation | PLoS ONE 7.7 (2012): e40887 | en_US |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10486/662651 | |
dc.description | Generalization of the dynamic clamp concept in neurophysiology and behavior. Chamorro et al. PLoS ONE. 2012. 7(7) doi: 10.1371/journal.pone.0040887 | en_US |
dc.description.abstract | The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons. In this paper we show that this concept can be easily generalized to build other kinds of closed-loop protocols beyond (or in addition to) electrical stimulation and recording in neurophysiology and behavioral studies for neuroethology. In particular, we illustrate three different examples of goal-driven real-time closed-loop interactions with drug microinjectors, mechanical devices and video event driven stimulation. Modern activity-dependent stimulation protocols can be used to reveal dynamics (otherwise hidden under traditional stimulation techniques), achieve control of natural and pathological states, induce learning, bridge between disparate levels of analysis and for a further automation of experiments. We argue that closed-loop interaction calls for novel real time analysis, prediction and control tools and a new perspective for designing stimulus-response experiments, which can have a large impact in neuroscience research. | en_US |
dc.description.sponsorship | This work was supported by Spanish MICINN (Ministerio de Ciencia e Innovacion) BFU2009-08473 and TIN-2010-19607. | en_US |
dc.format.extent | 10 pág. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | © 2012 Chamorro et al. | |
dc.subject.other | Animal behavior | en_US |
dc.subject.other | Electrical stimulation | en_US |
dc.subject.other | Fishes | en_US |
dc.subject.other | Gamma-aminobutyric | en_US |
dc.subject.other | Ganglia | en_US |
dc.subject.other | Membrane potential | en_US |
dc.subject.other | Microinjection | en_US |
dc.subject.other | Neurons | en_US |
dc.title | Generalization of the dynamic clamp concept in neurophysiology and behavior | en_US |
dc.type | article | en_US |
dc.subject.eciencia | Informática | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pone.0040887 | |
dc.identifier.doi | 10.1371/journal.pone.0040887 | |
dc.identifier.publicationfirstpage | e40887 | |
dc.identifier.publicationissue | 7 | |
dc.identifier.publicationlastpage | e40887 | |
dc.identifier.publicationvolume | 7 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.contributor.group | Neurocomputación Biológica (ING EPS-005) | es_ES |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Levi , Refael (263895) | |
dc.authorUAM | Varona Martínez, Pablo (258962) | |
dc.facultadUAM | Escuela Politécnica Superior | |