ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: A case control study
Entity
UAM. Departamento de Biología; UAM. Departamento de Farmacología; UAM. Departamento de PsiquiatríaPublisher
BioMed CentralDate
2011-06-09Citation
10.1186/1471-2350-12-81
BMC Medical Genetics 12 (2011): 81
ISSN
1471-2350DOI
10.1186/1471-2350-12-81Funded by
This study has been supported by grants EC07/90393, EC07/90466 and EC07/90604, from Fondo de Investigacion Sanitaria (FIS). Berta Almoguera’s work is supported by a Rio Hortega grant from Instituto de Salud Carlos III. Pedro Dorado is supported by the Instituto de Salud Carlos III-FIS and European Union (FEDER) grant CP06/00030Editor's Version
http://dx.doi.org/10.1186/1471-2350-12-81Subjects
IL-10 gene; Schizophrenia; Cytokine SNPs; MedicinaRights
© 2011 Almoguera et al; licensee BioMed Central Ltd.Abstract
Background: Three IL-10 gene promoter single nucleotide polymorphisms -1082G > A, -819C > T and -592C > A
and the haplotypes they define in Caucasians, GCC, ACC, ATA, associated with different IL-10 production rates, have
been linked to schizophrenia in some populations with conflicting results. On the basis of the evidence of the sexdependent
effect of certain genes in many complex diseases, we conducted a sex-stratified case-control
association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the
possible sex-specific genetic effect in a Spanish schizophrenic population.
Methods: 241 DSM-IV diagnosed Spanish schizophrenic patients and 435 ethnically matched controls were
genotyped for -1082G > A and -592C > A SNPs. Chi squared tests were performed to assess for genetic association
of alleles, genotypes and haplotypes with the disease.
Results: The -1082A allele (p = 0.027), A/A (p = 0.008) and ATA/ATA (p = 0.003) genotypes were significantly
associated with schizophrenia in females while neither allelic nor genotypic frequencies reached statistical
significance in the male population.
Conclusions: Our results highlight the hypothesis of an imbalance towards an inflammatory syndrome as the
immune abnormality of schizophrenia. Anyway, a better understanding of the involvement of the immune system
would imply the search of immune abnormalities in endophenotypes in whose sex and ethnicity might be
differential factors. It also reinforces the need of performing complex gene studies based on multiple cytokine
SNPs, including anti and pro-inflammatory, to clarify the immune system abnormalities direction in the etiology of
schizophrenia
Files in this item
Google Scholar:Almoguera, Berta
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Riveiro Álvarez, Rosa
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López-Castromán, Jorge
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Dorado, Pedro
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López-Rodríguez, Rosario
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Fernández -Navarro, Pablo
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Baca García, Enrique
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Fernández Piqueras, José
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Dal- Ré, Rafaël
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Abad Santos, Francisco
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LLerena, Adrián
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Ayuso, Carmen García
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