High resolution fluorescence imaging of cancers using lanthanide ion-doped upconverting nanocrystals

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dc.contributor.author Naccache, Rafik
dc.contributor.author Bogdan, Nicoleta
dc.contributor.author Sanz-Rodríguez, Francisco
dc.contributor.author Iglesias de la Cruz, María del Carmen
dc.contributor.author Juarranz, Ángeles
dc.contributor.author Vetrone, Fiorenzo
dc.contributor.author Jaque, Daniel
dc.contributor.author García Solé, José
dc.contributor.author Capobianco, John A.
dc.contributor.author Martín Rodríguez, Emma
dc.contributor.other UAM. Departamento de Biología es_ES
dc.date.accessioned 2015-01-12T17:54:00Z
dc.date.available 2015-01-12T17:54:00Z
dc.date.issued 2012-12-01
dc.identifier.citation Cancers 4.4 (2012): 1067-1105 en_US
dc.identifier.issn 2072-6694 es_ES
dc.identifier.uri http://hdl.handle.net/10486/663067
dc.description.abstract During the last decade inorganic luminescent nanoparticles that emit visible light under near infrared (NIR) excitation (in the biological window) have played a relevant role for high resolution imaging of cancer. Indeed, semiconductor quantum dots (QDs) and metal nanoparticles, mostly gold nanorods (GNRs), are already commercially available for this purpose. In this work we review the role which is being played by a relatively new class of nanoparticles, based on lanthanide ion doped nanocrystals, to target and image cancer cells using upconversion fluorescence microscopy. These nanoparticles are insulating nanocrystals that are usually doped with small percentages of two different rare earth (lanthanide) ions: The excited donor ions (usually Yb3+ ion) that absorb the NIR excitation and the acceptor ions (usually Er3+, Ho3+ or Tm3+), that are responsible for the emitted visible (or also near infrared) radiation. The higher conversion efficiency of these nanoparticles in respect to those based on QDs and GNRs, as well as the almost independent excitation/emission properties from the particle size, make them particularly promising for fluorescence imaging. The different approaches of these novel nanoparticles devoted to "in vitro" and "in vivo" cancer imaging, selective targeting and treatment are examined in this review en_US
dc.description.sponsorship J.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support of his research. J.A.C. and F.V. are grateful for financial support from the Natural Sciences and Engineering Research Council (NSERC) of Canada. R.N. is grateful for NSERC financial support through the Alexander Graham Bell Graduate Scholarship Program. B.F.Z. is grateful to les Fonds Québécois de Recherche sur la Nature et les Technologies (FQRNT) for financial support through the Graduate Scholarship Program. This work was also supported in part by the Universidad Autónoma de Madrid and Comunidad Autónoma de Madrid (Projects CCG087-UAM/MAT-4434 and S2009/MAT-1756), by the Spanish Ministerio de Educación y Ciencia (MAT 2010–16161). EMR acknowledges financial support from Fundación Alfonso Martín Escudero and Marie Curie IOF Fellowship Program (project 274404 LUNAMED) en_US
dc.format.extent 39 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher MDPI en_US
dc.relation.ispartof Cancers en_US
dc.rights © 2012 by the authors; licensee MDPI, Basel, Switzerland en_US
dc.subject.other Cancer es_ES
dc.subject.other Fluorescence imaging es_ES
dc.subject.other Lanthanide-doped nanocrystals es_ES
dc.subject.other Targeting es_ES
dc.subject.other Upconversion es_ES
dc.title High resolution fluorescence imaging of cancers using lanthanide ion-doped upconverting nanocrystals es_ES
dc.type article es_ES
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion http://dx.doi.org/10.3390/cancers4041067 es_ES
dc.identifier.doi 10.3390/cancers4041067 es_ES
dc.identifier.publicationfirstpage 1067 es_ES
dc.identifier.publicationissue 4 es_ES
dc.identifier.publicationlastpage 1105 es_ES
dc.identifier.publicationvolume 4 es_ES
dc.relation.projectID Comunidad de Madrid. S2009/MAT-1756/PHAMA es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/274404 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess es_ES
dc.authorUAM García Solé, José (259818)
dc.authorUAM Juarranz De La Fuente, Ángeles (261501)
dc.authorUAM Martín Rodríguez, Emma (263824)
dc.authorUAM Iglesias De La Cruz, María Del Carmen (261374)
dc.authorUAM Sanz Rodríguez, Francisco (260710)


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