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dc.contributor.authorLaime, Delia
dc.contributor.authorLlanqui, Octavio
dc.contributor.authorJuarranz de la Fuente, Ángeles 
dc.contributor.authorLuisa Botella, M.
dc.contributor.authorRamírez-García, José Ramón
dc.contributor.authorSanz Rodríguez, Francisco 
dc.contributor.otherUAM. Departamento de Biologíaes_ES
dc.date.accessioned2015-01-21T15:56:15Z
dc.date.available2015-01-21T15:56:15Z
dc.date.issued2012-09-01
dc.identifier.citationInternational Journal of Morphology 30. 3 (2012): 1115-1131en_US
dc.identifier.issn0717-9502 (online)en
dc.identifier.issn0717-9367 (print)en
dc.identifier.urihttp://hdl.handle.net/10486/663277
dc.description.abstractColorectal cancer (CRC) is the second most common type of cancer in the European population. Currently there molecular biomarkers that can be used for early detection of cancer of CRC. Is a tumor suppressor KLF6 associated with several types of cancers. Our hypothesis is that KLF6 can be an excellent marker for the early diagnosis of CRC. To study the implication of KLF6 in CRC, we selected 15 biopsies of each stage (T1, T2 and T3) from the archives of the Pathology Department of Defense Central Hospital Gómez-Ulla, which had areas of affected tissue (tumor) and unaffected areas (non-tumor). This study was performed histological, immunohistochemical and RT-PCR, based on the expression of three genes, markers Ki67 and p53 as positive and as a marker in KLF6 study. The results showed that the expression of KLF6 is directly related to increased malignancy cell adenocarcinomas, corroborated by RT-PCR, showing the gradual emergence of alternative forms processing, corresponding to no KLF6. This protein was expressed both cytoplasmic and nuclear in the early stages T1 and T2, disappearing at the nuclear level in the most advanced stage (T3). KLF6 conclude that a good CRC tumor marker because it shows patterns of expression level increased cytoplasmic and nuclear level decreasingen_US
dc.description.sponsorshipEste trabajo fue financiado por: Universidad de Tarapacá, Departamento de Biología “Proyecto Mayor Código 1042", Arica, Chile; Universidad Autónoma de Madrid, Facultad de Ciencias, Depto. de Citología y Facultad de Medicina; y Hospital Central de la Defensa Gómez-Ulla, Servicio de Anatomía Patológica de Madrid, Españaes_ES
dc.format.extent17 pag.en
dc.format.mimetypeapplication/pdfen
dc.language.isospaen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.rights© Copyright 2013 Elsevier B.V.en_US
dc.subject.otherColon canceren_US
dc.subject.otherKLF6en_US
dc.subject.otherAdenocarcinomaes_ES
dc.titleRole of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humanoen_US
dc.typearticleen
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.4067/S0717-95022012000300058es_ES
dc.identifier.doi10.4067/S0717-95022012000300058es_ES
dc.identifier.publicationfirstpage1115es_ES
dc.identifier.publicationissue3es_ES
dc.identifier.publicationlastpage1131es_ES
dc.identifier.publicationvolume30es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMJuarranz De La Fuente, Ángeles (261501)
dc.authorUAMSanz Rodríguez, Francisco (260710)
dc.facultadUAMFacultad de Ciencias


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