Amelioration of Ischemic brain damage by peritoneal dialysis
Entity
UAM. Departamento de MedicinaPublisher
American Society for Clinical InvestigationDate
2013-10-01Citation
10.1172/JCI67284
The Journal of Clinical Investigation 123.10 (2013): 4359-4363
ISSN
0021-9738 (print); 1558-8238 (online)DOI
10.1172/JCI67284Funded by
This work was supported by grants from the Spanish MINECO to J. Sánchez-Prieto (BFU2010/16947), I. Lizasoain (SAF2011- 23354), and M.A. Moro (SAF2009-08145, SAF2012-33216, and CSD2010-00045); from Fondo Europeo de Desarrollo Regional (FEDER) “Instituto de Salud Carlos III” (RD06/0026, RD12/0014) to I. Lizasoain, M. Torres, J. Vivancos, and J. Sánchez-Prieto; from the “Comunidad de Madrid” (CAM-I2M2 2011-BMD-2349) to I. Lizasoain, M. Torres, J. Vivancos, and J. Sánchez-Prieto; and from NEUROSTEMCM to M.A. Moro (S2010/BMD-2336). Research in the laboratory of S. Canals and J. Lerma is supported by grants from the Spanish MINECO (BFU2009-09938, BFU2011-24084, and CSD2007-00023)Project
Comunidad de Madrid. S2010/BMD-2336/NEUROSTEM; Comunidad de Madrid. S2010/BMD-2349/I2M2Subjects
brain hemorrhage; brain ischemia; chronic kidney disease; peritoneal dialysis; endothelium cell; MedicinaAbstract
Ischemic stroke is a devastating condition, for which there is still no effective therapy. Acute ischemic stroke is associated with high concentrations of glutamate in the blood and interstitial brain fluid. The inability of the tissue to retain glutamate within the cells of the brain ultimately provokes neuronal death. Increased concentrations of interstitial glutamate exert further excitotoxic effects on healthy tissue surrounding the infarct zone. We developed a strategy based on peritoneal dialysis to reduce blood glutamate levels, thereby accelerating brain-to-blood glutamate clearance. In a rat model of stroke, this simple procedure reduced the transient increase in glutamate, consequently decreasing the size of the infarct area. Functional magnetic resonance imaging demonstrated that the rescued brain tissue remained functional. Moreover, in patients with kidney failure, peritoneal dialysis significantly decreased glutamate concentrations. Our results suggest that peritoneal dialysis may represent a simple and effective intervention for human stroke patients
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Google Scholar:Del Carmen Godino, María
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Romera, Víctor G.
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Sánchez-Tomero, José Antonio
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Pacheco, Jesus
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Canals, Santiago
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Lerma, Juan
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Vivancos, José
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Moro, María Ángeles
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Torres, Magdalena
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Lizasoaín, Ignacio
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Sánchez-Prieto, José
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