Astrocytes mediate in vivo cholinergic-induced synaptic plasticity
Entity
UAM. Departamento de Anatomía, Histología y NeurocienciaPublisher
Public Library of ScienceDate
2012-02-01Citation
10.1371/journal.pbio.1001259
PLoS Biology 10.2 (2012): e1001259
ISSN
1544-9173 (print); 1545-7885 (online)DOI
10.1371/journal.pbio.1001259Funded by
Supported by grants from Ministerio de Ciencia e Innovacio´n (BFU2010-15832, BFU2008-03488, BFU2008-04196, CSD2010-00045), Spain, European Union (HEALTH-F2-2007-202167) and Cajal Blue Brain. G.P. is supported by a Marie Curie Fellowship (FP7-253635). E.D.M. is supported by INCRECyT project from European Social Fund and JCCM.Project
info:eu-repo/grantAgreement/EC/FP7/253635; info:eu-repo/grantAgreement/EC/FP7/202167Subjects
Astrocytes; Cholinergic Neurons; Hippocampus; Long-Term Potentiation; Inbred C57BL; Muscarinic Antagonists; Synaptic Transmission; MedicinaRights
© 2012 Navarrete et al.Abstract
Long-term potentiation (LTP) of synaptic transmission represents the cellular basis of learning and memory. Astrocytes have
been shown to regulate synaptic transmission and plasticity. However, their involvement in specific physiological processes
that induce LTP in vivo remains unknown. Here we show that in vivo cholinergic activity evoked by sensory stimulation or
electrical stimulation of the septal nucleus increases Ca2+ in hippocampal astrocytes and induces LTP of CA3-CA1 synapses,
which requires cholinergic muscarinic (mAChR) and metabotropic glutamate receptor (mGluR) activation. Stimulation of
cholinergic pathways in hippocampal slices evokes astrocyte Ca2+ elevations, postsynaptic depolarizations of CA1 pyramidal
neurons, and LTP of transmitter release at single CA3-CA1 synapses. Like in vivo, these effects are mediated by mAChRs, and
this cholinergic-induced LTP (c-LTP) also involves mGluR activation. Astrocyte Ca2+ elevations and LTP are absent in IP3R2
knock-out mice. Downregulating astrocyte Ca2+ signal by loading astrocytes with BAPTA or GDPbS also prevents LTP, which
is restored by simultaneous astrocyte Ca2+ uncaging and postsynaptic depolarization. Therefore, cholinergic-induced LTP
requires astrocyte Ca2+ elevations, which stimulate astrocyte glutamate release that activates mGluRs. The cholinergicinduced
LTP results from the temporal coincidence of the postsynaptic activity and the astrocyte Ca2+ signal simultaneously
evoked by cholinergic activity. Therefore, the astrocyte Ca2+ signal is necessary for cholinergic-induced synaptic plasticity,
indicating that astrocytes are directly involved in brain storage information
Files in this item
Google Scholar:Navarrete, Marta
-
Perea, Gertrudis
-
Fernández de Sevilla García, David
-
Gómez-Gonzalo, Marta
-
Núñez Molina, Ángel
-
Martín, Eduardo D.
-
Araque, Alfonso
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Population-based multicase-control study in common tumors in Spain (MCC-Spain): Rationale and study design
Castaño-Vinyals, Gemma; Aragonés, Nuria; Pérez-Gómez, Beatriz; Martín, Vicente; Llorca, Javier; Moreno, Víctor; Altzibar, Jone M.; Ardanaz, Eva; De Sanjosé, Sílvia; Jiménez-Moleón, José J.; Tardón, Adonina; Alguacil, Juan; Peiró, Rosana; Marcos-Gragera, Rafael; Navarro, Carmen; Pollán Santamaría, Marina Anunciación; Kogevinas, Manolis; Alonso, Maria Teresa; Amiano, Pilar; Arias, Cristina; Azpiri, Mikel; Benavente, Yolanda; Boldo, Elena; Bueno, Aurora; Bustamante, Mariona; Caballero, Francisco Javier; Campo, Elías; Cantón, Rafael; Capelo, Rocío; Carmona, Carme; Casabonne, Delphine; Chirlaque, María Dolores; Cirac, Judith; Clofent, Juan; Colado, Enrique; Costas, Laura; Crous, Marta; Campo, Rosa del; Díaz Santos, Marian; Dierssen-Sotos, Trinidad; Ederra, María; Espinosa, Ana; Fernández Cabrera, Marieta; Fernández Somoano, Ana; Fernández Villa, Tania; García García-Esquinas, Esther; García Martín, Paloma; Gómez-Acebo, Inés; Puga, Cristina González; Gràcia, Esther; Eslava, Marcela Guevara; Guinó, Elisabet; Huerta, José María; Lope, Virginia; López-Abente, Gonzalo; López-Otín, Carlos; Martínez Argüelles, Begoña; Merino Salas, Sergio; Mirón Pozo, Benito; Molina dee La Torre, Antonio José; Moreno, Eduardo; Moreno Iribas, Concepción; Olea, Nicolás; Gelis, Gemma Osca; Paré, Laia; Porta, Miquel; Puig, Montse; Rivad del Fresno, Manuel; Robles, Claudia; Rodríguez Suarez, Marta María; Romero, Beatriz; Sáez Castillo, Ana Isabel; Sala Serra, Maria
2015-01-01