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α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach

dc.contributor.authorMatesanz García, Ana Isabel 
dc.contributor.authorSouza, Pilar
dc.contributor.otherUAM. Departamento de Química Inorgánicaes_ES
dc.date.accessioned2015-04-22T08:53:19Z
dc.date.available2015-04-22T08:53:19Z
dc.date.issued2009-12-01
dc.identifier.citationMini-Reviews in Medicinal Chemistry 9.12 (2009): 1389-1396en_US
dc.identifier.issn1389-5575 (print)es_ES
dc.identifier.issn1875-5607 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/665374
dc.description.abstractα-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationshipsen_US
dc.description.sponsorshipThe authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spainen_US
dc.format.extent8 pag.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofMini-Reviews in Medicinal Chemistryen_US
dc.rights© 2009 Bentham Science Publishers Ltd.en_US
dc.subject.otherα-N-heterocyclic thiosemicarbazoneen_US
dc.subject.otherAntitumour agentsen_US
dc.subject.otherBis(thiosemicarbazone)en_US
dc.subject.otherMetal complexesen_US
dc.subject.otherRibonucleotide reductase inhibitorsen_US
dc.subject.otherStructure-activity relationshipsen_US
dc.titleα-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approachen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.2174/138955709789957422es_ES
dc.identifier.doi10.2174/138955709789957422es_ES
dc.identifier.publicationfirstpage1389es_ES
dc.identifier.publicationissue12es_ES
dc.identifier.publicationlastpage1396es_ES
dc.identifier.publicationvolume9es_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Ciencias


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