dc.contributor.author | Rodriguez, Ariel | |
dc.contributor.author | Falcón, Ana María | |
dc.contributor.author | Cuevas, María Teresa | |
dc.contributor.author | Pozo, Francisco | |
dc.contributor.author | Guerra García, María Susana | |
dc.contributor.author | García-Barreno, Blanca | |
dc.contributor.author | Martínez-Orellana, Pamela | |
dc.contributor.author | Pérez-Breña, Pilar | |
dc.contributor.author | Montoya, María | |
dc.contributor.author | Melero, José Antonio | |
dc.contributor.author | Pizarro, Manuel | |
dc.contributor.author | Ortín, Juan | |
dc.contributor.author | Casas, Inmaculada | |
dc.contributor.author | Nieto, Amelia | |
dc.contributor.other | UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología | es_ES |
dc.date.accessioned | 2015-06-18T09:46:09Z | |
dc.date.available | 2015-06-18T09:46:09Z | |
dc.date.issued | 2013-01-17 | |
dc.identifier.citation | Plos One 8.1 (2013): e53515 | en_US |
dc.identifier.issn | 1932-6203 (online) | en_US |
dc.identifier.uri | http://hdl.handle.net/10486/666900 | |
dc.description.abstract | Pandemic 2009 H1N1 (pH1N1) influenza viruses caused mild symptoms in most infected patients. However, a greater rate of severe disease was observed in healthy young adults and children without co-morbid conditions. Here we tested whether influenza strains displaying differential virulence could be present among circulating pH1N1 viruses. The biological properties and the genotype of viruses isolated from a patient showing mild disease (M) or from a fatal case (F), both without known co-morbid conditions were compared in vitro and in vivo. The F virus presented faster growth kinetics and stronger induction of cytokines than M virus in human alveolar lung epithelial cells. In the murine model in vivo, the F virus showed a stronger morbidity and mortality than M virus. Remarkably, a higher proportion of mice presenting infectious virus in the hearts, was found in F virus-infected animals. Altogether, the data indicate that strains of pH1N1 virus with enhanced pathogenicity circulated during the 2009 pandemic. In addition, examination of chemokine receptor 5 (CCR5) genotype, recently reported as involved in severe influenza virus disease, revealed that the F virus-infected patient was homozygous for the deleted form of CCR5 receptor (CCR5Δ32) | en_US |
dc.description.sponsorship | This work was supported by Instituto de Salud Carlos III (Programa especial de investigación sobre la gripe pándemica GR09/0023, GR09/0040, GR09/
0039) and Ciber de Enfermedades Respiratorias | en_US |
dc.format.extent | 12 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | Plos One | en_US |
dc.rights | © 2013 Rodriguez et al. | es_ES |
dc.subject.other | Amino Acids | en_US |
dc.subject.other | Cells | en_US |
dc.subject.other | Immunohistochemistry | en_US |
dc.subject.other | Influenza | en_US |
dc.subject.other | Pandemics | en_US |
dc.subject.other | Inbred BALB C | en_US |
dc.title | Characterization In vitro and In vivo of a pandemic H1N1 influenza virus from a fatal case | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0053515 | es_ES |
dc.identifier.publicationfirstpage | e53515 | es_ES |
dc.identifier.publicationissue | 1 | es_ES |
dc.identifier.publicationlastpage | e53515 | es_ES |
dc.identifier.publicationvolume | 8 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |