dc.contributor.author | Martín-Cófreces, Noa | |
dc.contributor.author | Alarcón, Balbino | |
dc.contributor.author | Sánchez Madrid, Francisco | |
dc.contributor.other | UAM. Departamento de Biología Molecular | es_ES |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.date.accessioned | 2015-07-06T11:38:40Z | |
dc.date.available | 2015-07-06T11:38:40Z | |
dc.date.issued | 2011-12-01 | |
dc.identifier.citation | Frontiers in Immunology 2 (2011): 24 | en_US |
dc.identifier.issn | 1664-3224 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/667260 | |
dc.description | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission | en_US |
dc.description.abstract | T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However,growing evidence shows that their roles on Tcell activation are more dynamic than merely serving as tracks or scaffold for different mol-ecules.The crosstalk between both skeletons may be important for the formation and movement of the lamella at the immunological synapse by increasing the adhsion of the T cell to the antigen-presenting cells (APC), thus favoring the transport of components toward the plasma membrane and in turn regulating theT-APC intercellular communication. Microtubules and F-actin appear to be essential for the transport of thed ifferent signaling microclusters along the membrane, therefore facilitating the propagation of the signal. Finally,they can also be important for regulating the endocytosis, recycling, and degrada-tion of the Tcell receptor signaling machinery, thus helping both to sustain the activated state and to switch it off | en_US |
dc.description.sponsorship | This work was supported by grantsf rom Spanish Ministry of
Science and Innovation (SAF2008-02635), INSINET 0159/2006
from Comunidad de Madrid, Red RECAVARD 06/0014-0030, and
the Centro Nacional de Investigaciones Cardiovasculares (CNIC,
Spain), which is supported by the Spanish Ministry of Science and
Innovation and the Pro-CNIC Foundation. | en_US |
dc.format.extent | 6 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Frontiers Research Foundation | en_US |
dc.relation.ispartof | Frontiers in Immunology | en_US |
dc.rights | © 2011 Martín-Cófreces, Alarcón and Sánchez-Madrid | es_ES |
dc.subject.other | Actin | en_US |
dc.subject.other | Immune synapse | en_US |
dc.subject.other | Microtubule-organizing centre | en_US |
dc.subject.other | T cell | en_US |
dc.title | Tubulin and actin interplay at thet cell and antigen-presenting cell interface | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fimmu.2011.00024 | es_ES |
dc.identifier.doi | 10.3389/fimmu.2011.00024 | es_ES |
dc.identifier.publicationfirstpage | 24 | es_ES |
dc.identifier.publicationlastpage | 24 | es_ES |
dc.identifier.publicationvolume | 2 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Sánchez Madrid, Francisco (259404) | |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Centro de Biología Molecular Severo Ochoa (CBMSO) | |
dc.institutoUAM | Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa) | |