Tau protein and adult hippocampal neurogenesis
Entity
UAM. Departamento de Biología MolecularPublisher
Frontiers EditorialDate
2012-08-24Citation
10.3389/fnins.2012.00104
Frontiers in Neuroscience 6 (2012): 1-6
ISSN
1662-4548 (print); 1662-453X (online)DOI
10.3389/fnins.2012.00104Funded by
This study was funded by grants from the Spanish Ministry of Health (SAF2006-02424; SAF2010-15525), Comunidad de Madrid (S2010/BMD-2331), Fundación CIEN (PI008-09), Fundación M.Botín, and an institutional grant from Fundación R. ArecesProject
Comunidad de Madrid. S2010/BMD-2331/NEURODEGMODELSEditor's Version
http://dx.doi.org/10.3389/fnins.2012.00104Subjects
Adult neurogenesis; Hippocampus; Phosphorylation; Splicing; Tau; Biología y Biomedicina / BiologíaRights
© 2012 Fuster-Matanzo, Llorens-Martín, Jurado-Arjona, Ávila and HernándezAbstract
Tau protein is a microtubule-associated protein found in the axonal compartment that
stabilizes neuronal microtubules under normal physiological conditions. Tau metabolism
has attracted much attention because of its role in neurodegenerative disorders called
tauopathies, mainly Alzheimer disease. Here, we review recent findings suggesting that
axonal outgrowth in subgranular zone during adult hippocampal neurogenesis requires a
dynamic microtubule network and tau protein facilitates to maintain that dynamic cytoskeleton.
Those functions are carried out in part by tau isoform with only three microtubulebinding
domains (without exon 10) and by presence of hyperphosphorylated tau forms.
Thus, tau is a good marker and a valuable tool to study new axons in adult neurogenesis
Files in this item
Google Scholar:Fuster-Matanzo, Almudena
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Llorens-Martín, María
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Jurado-Arjona, Jerónimo
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Avila, Jesús
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Hernández Pérez, Félix
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