Optimization problems in electron microscopy of single particles

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dc.contributor.author Sorzano, Carlos Oscar S.
dc.contributor.author Marabini, Roberto
dc.contributor.author Pascual-Montano, Alberto
dc.contributor.author Scheres, Sjors H W
dc.contributor.author Carazo García, José María
dc.contributor.other UAM. Departamento de Ingeniería Informática es_ES
dc.date.accessioned 2015-07-14T07:08:08Z
dc.date.available 2015-07-14T07:08:08Z
dc.date.issued 2006
dc.identifier.citation Annals of Operations Research 148.1 (2006): 133-165 en_US
dc.identifier.issn 0254-5330 (print) en_US
dc.identifier.issn 1572-9338 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/667375
dc.description The final publication is available at Springer via http://dx.doi.org/10.1007/s10479-006-0078-8 en_US
dc.description.abstract Electron Microscopy is a valuable tool for the elucidation of the three-dimensional structure of macromolecular complexes. Knowledge about the macromolecular structure provides important information about its function and how it is carried out. This work addresses the issue of three-dimensional reconstruction of biological macromolecules from electron microscopy images. In particular, it focuses on a methodology known as “single-particles” and makes a thorough review of all those steps that can be expressed as an optimization problem. In spite of important advances in recent years, there are still unresolved challenges in the field that offer an excellent testbed for new and more powerful optimization techniques. en_US
dc.description.sponsorship We acknowledge partial support from the “Comunidad Autónoma de Madrid” through grants CAM-07B-0032-2002, GR/SAL/0653/2004 and GR/SAL/0342/2004, the “Comisión Interministerial de Ciencia yTecnologia” of Spain through grants BIO2001-1237, BIO2001-4253-E, BIO2001-4339-E, BIO2002- 10855-E, BFU2004-00217/BMC, the Spanish FIS grant (G03/185), the European Union through grants QLK2- 2000-00634, QLRI-2000-31237, QLRT-2000-0136, QLRI-2001-00015, FP6-502828 and the NIH through grant HL70472. Alberto Pascual and Roberto Marabini acknowledge support by the Spanish Ramon y Cajal Program. en_US
dc.format.extent 34 pág. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Springer Berlin Heidelberg
dc.relation.ispartof Annals of Operations Research en_US
dc.rights © Springer-Verlag Berlin Heidelberg 2006
dc.subject.other Electron microscopy en_US
dc.subject.other Optimization en_US
dc.subject.other Single particles en_US
dc.title Optimization problems in electron microscopy of single particles en_US
dc.type article en_US
dc.subject.eciencia Informática es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s10479-006-0078-8
dc.identifier.doi 10.1007/s10479-006-0078-8
dc.identifier.publicationfirstpage 133
dc.identifier.publicationissue 1
dc.identifier.publicationlastpage 165
dc.identifier.publicationvolume 148
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/502828 en
dc.type.version info:eu-repo/semantics/acceptedVersion en
dc.contributor.group Tratamiento de Señales Biomédicas (ING EPS-011) es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Marabini Ruiz, Roberto (260858)

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