Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain
Author
García-Agúndez, José Augusto; Abad Santos, Francisco; Aldea, Ana; Alonso-Navarro, Hortensia; Bernal, María Luisa; Borobia Pérez, Alberto M.; Borràs, Emma; Carballo, Miguel; Carvajal, Alfonso; García-Muñiz, José D.; Gervasini, Guillermo; Jiménez-Jiménez, Félix Javier; Lucena, María Isabel; Martínez, Carmen; Sacristán, José A.; Salado, Inés; Sinués, Blanca; Vicente, Jorge; García-Martín, ElenaEntity
UAM. Departamento de FarmacologíaPublisher
Frontiers Research FoundationDate
2012-12-01Citation
10.3389/fgene.2012.00273
Frontiers in Genetics 3 (2012): 273
ISSN
1664-8021DOI
10.3389/fgene.2012.00273Funded by
The work in the author’s laboratory is financed by Grants PS09/00943, PS09/00469, RETICS RIRAAF RD07/0064/0016, and CIBERehd from Instituto de Salud CarlosIII,Madrid, Spain, and by Grants GR10068 from Junta de Extremadura, Spain. Financed in part with FEDER funds from the European UnionProject
Gobierno de España. RD07/0064/0016Editor's Version
http://dx.doi.org/10.3389/fgene.2012.00273Subjects
Adverse drug reactions; Biomarkers; Clinical recommendations; Clinical relevance; Pharmacogenomics; FarmaciaAbstract
The development of clinica lpractice recommendations or
guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in recent years.However,several barriers to implementing the use of pharmacogenomics testing exist.We conducted a survey among members of the Spanish Societies of Pharmacology and Clinical Pharmacology to obtain information about the perception of such barriers and to compare the perceptions of participants about the relative importance of majorgene/drug pairs.Of 11 potential barriers,the highest importance was attributed to lack of institutional support for pharmacogenomic stesting,and to the issues related to the lack of guidelines.Of the proposed gene/drug pairs the highest importance was assigned to HLA-B/abacavir, UGT1A1/irinotecan, and CYP2D6/tamoxifen.In this perspective article,we compare the relative importance of 29 gene/drugpairs in the Spanish study with that of the same pairs in the American Society for Clinical Pharmacology and Therapeutic sstudy,and we provide suggestions and areas of focus to develop a guide for clinical practice in pharmacogenomics testing
Files in this item
Google Scholar:García-Agúndez, José Augusto
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Abad Santos, Francisco
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Aldea, Ana
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Alonso-Navarro, Hortensia
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Bernal, María Luisa
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Borobia Pérez, Alberto M.
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Borràs, Emma
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Carballo, Miguel
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Carvajal, Alfonso
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García-Muñiz, José D.
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Gervasini, Guillermo
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Jiménez-Jiménez, Félix Javier
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Lucena, María Isabel
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Martínez, Carmen
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Sacristán, José A.
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Salado, Inés
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Sinués, Blanca
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Vicente, Jorge
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García-Martín, Elena
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