Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats

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dc.contributor.author Brito, Julio P.
dc.contributor.author Siques, Patricia
dc.contributor.author Arribas, Silvia M.
dc.contributor.author López de Pablo, Ángel L.
dc.contributor.author González, M. Carmen
dc.contributor.author Naveas, Nelson
dc.contributor.author Arriaza, Karem
dc.contributor.author Flores, Karen
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Pulido, Ruth
dc.contributor.author Ordenes, Stefany
dc.contributor.author López, M. Rosario
dc.contributor.other UAM. Departamento de Fisiología es_ES
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.date.accessioned 2016-06-15T17:12:20Z
dc.date.available 2016-06-15T17:12:20Z
dc.date.issued 2015-01-01
dc.identifier.citation BioMed Research International 2015 (2015): 169841 en_US
dc.identifier.issn 2314-6133 es_ES
dc.identifier.uri http://hdl.handle.net/10486/671444
dc.description.abstract Long-termchronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, 𝑛 = 9) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, 𝑛 = 10) in a chamber (428 Torr, 4,600m of altitude) for 46 days and compared to rats under normoxia (NX, 𝑛 = 10). Body weight, hematocrit, and right ventricle ratio were measured. Pulmonary artery remodeling was assessed using confocal microscopy of tissues stained with a nuclear dye (DAPI) and CD11b antibody. Both hypoxic conditions exhibited increased hematocrit and hypertrophy of the right ventricle, tunica adventitia, and tunica media, with no changes in lumen size. The medial hypertrophy area (larger in CH) depicted a significant increase in smooth muscle cell number. Additionally, CIH2x2 increased the adventitial hypertrophy area, with an increased cellularity and a larger prevalence of clustered inflammatory cells. In conclusion, CIH2x2 elicitsmilder effects on pulmonary artery medial layermuscularization and subsequent right ventricular hypertrophy than CH. However, CIH2x2 induces greater and characteristic alterations of the adventitial layer en_US
dc.description.sponsorship This work was funded by GORE-FNDR-BIP: 30125349-0, AECID Nº A/030023/10, and CYTED-ALTMEDFIS grants en_US
dc.format.extent 11 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.ispartof BioMed Research International en_US
dc.rights © 2015 Julio Brito et al. es_ES
dc.subject.other Hipoxia es_ES
dc.subject.other Pulmonary artery en_US
dc.title Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1155/2015/169841 es_ES
dc.identifier.doi 10.1155/2015/169841 es_ES
dc.identifier.publicationfirstpage 1 es_ES
dc.identifier.publicationlastpage 11 es_ES
dc.identifier.publicationvolume 2015 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en_US
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Arribas Rodríguez, Silvia Magdalena (259509)
dc.authorUAM López De Pablo León, Ángel Luis (259961)


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