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dc.contributor.authorBrito, Julio P.
dc.contributor.authorSiques, Patricia
dc.contributor.authorArribas Rodríguez, Silvia Magdalena 
dc.contributor.authorLópez de Pablo León, Ángel Luis 
dc.contributor.authorGonzález Enguita, María del Carmen 
dc.contributor.authorNaveas, Nelson
dc.contributor.authorArriaza, Karem
dc.contributor.authorFlores, Karen
dc.contributor.authorLeón-Velarde, Fabiola
dc.contributor.authorPulido, Ruth
dc.contributor.authorOrdenes, Stefany
dc.contributor.authorLópez, M. Rosario
dc.contributor.otherUAM. Departamento de Fisiologíaes_ES
dc.contributor.otherUAM. Departamento de Medicina Preventiva y Salud Pública y Microbiologíaes_ES
dc.date.accessioned2016-06-15T17:12:20Z
dc.date.available2016-06-15T17:12:20Z
dc.date.issued2015-01-01
dc.identifier.citationBioMed Research International 2015 (2015): 169841en_US
dc.identifier.issn2314-6133es_ES
dc.identifier.urihttp://hdl.handle.net/10486/671444
dc.description.abstractLong-termchronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, 𝑛 = 9) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, 𝑛 = 10) in a chamber (428 Torr, 4,600m of altitude) for 46 days and compared to rats under normoxia (NX, 𝑛 = 10). Body weight, hematocrit, and right ventricle ratio were measured. Pulmonary artery remodeling was assessed using confocal microscopy of tissues stained with a nuclear dye (DAPI) and CD11b antibody. Both hypoxic conditions exhibited increased hematocrit and hypertrophy of the right ventricle, tunica adventitia, and tunica media, with no changes in lumen size. The medial hypertrophy area (larger in CH) depicted a significant increase in smooth muscle cell number. Additionally, CIH2x2 increased the adventitial hypertrophy area, with an increased cellularity and a larger prevalence of clustered inflammatory cells. In conclusion, CIH2x2 elicitsmilder effects on pulmonary artery medial layermuscularization and subsequent right ventricular hypertrophy than CH. However, CIH2x2 induces greater and characteristic alterations of the adventitial layeren_US
dc.description.sponsorshipThis work was funded by GORE-FNDR-BIP: 30125349-0, AECID Nº A/030023/10, and CYTED-ALTMEDFIS grantsen_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofBioMed Research Internationalen_US
dc.rights© 2015 Julio Brito et al.es_ES
dc.subject.otherHipoxiaes_ES
dc.subject.otherPulmonary arteryen_US
dc.titleAdventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in ratsen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1155/2015/169841es_ES
dc.identifier.doi10.1155/2015/169841es_ES
dc.identifier.publicationfirstpage1es_ES
dc.identifier.publicationlastpage11es_ES
dc.identifier.publicationvolume2015es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMArribas Rodríguez, Silvia Magdalena (259509)
dc.authorUAMLópez De Pablo León, Ángel Luis (259961)
dc.facultadUAMFacultad de Medicina


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