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Generation of a human iPSC line from a patient with a defect of intergenomic communication

dc.contributor.authorZurita, Francisco
dc.contributor.authorGalera, Teresa
dc.contributor.authorGonzález-Páramos, Cristina
dc.contributor.authorMoreno-Izquierdo, Ana
dc.contributor.authorSchneiderat, Peter
dc.contributor.authorFraga, Mario F.
dc.contributor.authorFernández, Agustin F.
dc.contributor.authorGaresse Alarcón, Rafael 
dc.contributor.authorGallardo, M. Esther
dc.contributor.otherUAM. Departamento de Bioquímicaes_ES
dc.contributor.otherInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)es_ES
dc.date.accessioned2017-03-31T11:08:07Z
dc.date.available2017-03-31T11:08:07Z
dc.date.issued2016-01-01
dc.identifier.citationStem Cell Research 16 (2016): 120-123en_US
dc.identifier.issn1873-5061es_ES
dc.identifier.urihttp://hdl.handle.net/10486/677855
dc.description.abstractHuman iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus.en_US
dc.description.sponsorshipThis work was supported by grants from the “Centro de Investigación Biomédica en Red en enfermedades raras” (CIBERER) (Grant 13-717/132.05 to RG), the “Instituto de Salud Carlos III” [Fondo de Investigación Sanitaria and Regional development fund (ERDF/FEDER) funds PI10/0703 and PI13/00556 to RG and PI15/00484 to MEG], “Comunidad Autónoma de Madrid” (Grant number S2010/BMD-2402 to RG); TG receives grant support from the Universidad Autónoma de Madrid (FPI-UAM) and FZD from the Ministerio de Educación, Cultura y Deporte (Grant FPU13/00544). MEG is staff scientist at the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER)en_US
dc.format.extent4 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevier B.V.es_ES
dc.relation.ispartofStem Cell Researchen_US
dc.rights© 2015 The Authorsen_US
dc.subject.otherIPSC lineen_US
dc.subject.otherPG64SV.2en_US
dc.subject.otherMutation (c.2243GNC; p.Trp748Ser)en_US
dc.subject.otherGene (POLG)en_US
dc.subject.otherSendai virusen_US
dc.titleGeneration of a human iPSC line from a patient with a defect of intergenomic communicationen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.scr.2015.12.016es_ES
dc.identifier.doi10.1016/j.scr.2015.12.016es_ES
dc.identifier.publicationfirstpage120es_ES
dc.identifier.publicationissue16es_ES
dc.identifier.publicationlastpage123es_ES
dc.relation.projectIDComunidad de Madrid. S2010/BMD-2402 MITOLAB-CMes_ES
dc.relation.projectIDGobierno de España. FPU13/00544es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimiento – NoComercial – SinObraDerivadaes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMGaresse Alarcón, Rafael (259828)
dc.facultadUAMFacultad de Medicina
dc.institutoUAMInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)


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