Ingested nitrate and breast cancer in the spanish multicase-control study on cancer (MCC-Spain)

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dc.contributor.author Espejo-Herrera, Nadia
dc.contributor.author Gracia-Lavedan, Esther
dc.contributor.author Pollan, Marina
dc.contributor.author Aragonés, Nuria
dc.contributor.author Boldo, Elena
dc.contributor.author Pérez-Gómez, Beatriz
dc.contributor.author Altzibar, Jone M.
dc.contributor.author Amiano, Pilar
dc.contributor.author Jiménez Zabala, Ana
dc.contributor.author Ardanaz, Eva
dc.contributor.author Guevara, Marcela
dc.contributor.author Molina, Antonio J.
dc.contributor.author Barrio, Juan Pablo
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Tardón, Adonina
dc.contributor.author Peiró, Rosana
dc.contributor.author Chirlaque, María Dolores
dc.contributor.author Palau, Margarita
dc.contributor.author Muñoz, Montse
dc.contributor.author Font-Ribera, Laia
dc.contributor.author Castaño-Vinyals, Gema
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Villanueva, Cristina M.
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.date.accessioned 2017-04-03T13:06:21Z
dc.date.available 2017-04-03T13:06:21Z
dc.date.issued 2016-07-01
dc.identifier.citation Environmental Health Perspectives 124.7 (2016): 1042-1049 en_US
dc.identifier.issn 0091-6765 (print) es_ES
dc.identifier.issn 1552-9924 (online) es_ES
dc.identifier.uri http://hdl.handle.net/10486/677871
dc.description.abstract Background: Ingested nitrate leads to endogenous formation of N-nitroso compounds that are breast carcinogens in animals, but human evidence is limited. oBjective: We evaluated ingested nitrate as a risk factor for breast cancer (BC) in a multicase-control study. Methods: Hospital-based incident BC cases and population-based controls were recruited in eight Spanish regions in 2008-2013; participants provided residential and water consumption from 18 years of age and information on known BC risk factors. Long-term nitrate levels (1940-2010) were estimated and linked with residential histories and water consumption to calculate waterborne ingested nitrate (milligrams/day). Dietary ingested nitrate (milligrams/day) was calculated using food frequency questionnaires and published dietary nitrate contents. Interactions with endogenous nitrosation factors and other variables were evaluated. A total of 1,245 cases and 1,520 controls were included in the statistical analysis. results: Among the study regions, average ± SD waterborne ingested nitrate ranged from 2.9 ± 1.9 to 13.5 ± 7.5 mg/day, and dietary ingested nitrate ranged from 88.5 ± 48.7 to 154 ± 87.8 mg/day. Waterborne ingested nitrate was not associated with BC overall, but among postmenopausal women, those with both high nitrate (> 6 vs. < 2.6 mg/day) and high red meat intake (≥ 20 vs. < 20 g/day) were more likely to be cases than women with low nitrate and low red meat intake (adjusted odds ratio = 1.64; 95% confidence interval: 1.08, 2.49; overall interaction p-value = 0.17). No association was found with dietary nitrate. conclusions: Waterborne ingested nitrate was associated with BC only among postmenopausal women with high red meat consumption. Dietary nitrate was not associated with BC regardless of the animal or vegetable source or of menopausal status. en_US
dc.description.sponsorship This study was funded by the “Acción Transversal del Cáncer del Consejo de Ministros del 11/10/2007” from the “Instituto de Salud Carlos III-FEDER” (PI08/1770, PI08/0533, PI11/00226), ISCIII FIS Ph.D. program from the “Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR FI-DGR 2013) Generalitat de Cataluña.” en_US
dc.format.extent 8 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher National Institute of Environmental Health Sciences (NIEHS) en_US
dc.relation.ispartof Environmental Health Perspectives en_US
dc.rights © 2016, Public Health Services, US Dept of Health and Human Services en_US
dc.subject.other Nitrate en_US
dc.subject.other Breast cancer en_US
dc.subject.other Spanish regions en_US
dc.subject.other Postmenopausal women en_US
dc.title Ingested nitrate and breast cancer in the spanish multicase-control study on cancer (MCC-Spain) en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1289/ehp.1510334 es_ES
dc.identifier.doi 10.1289/ehp.1510334 es_ES
dc.identifier.publicationfirstpage 1042 es_ES
dc.identifier.publicationissue 7 es_ES
dc.identifier.publicationlastpage 1049 es_ES
dc.identifier.publicationvolume 124 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM Pollán Santamaría, Marina Anunciación (262007)


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