Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair
Entity
UAM. Departamento de Medicina; Instituto de Investigación del Hospital de La Princesa (IP)Publisher
eLife Sciences Publications LtdDate
2016-06-15Citation
10.7554/eLife.15251.001
eLife 5 (2016): e15251
ISSN
2050-084XDOI
10.7554/eLife.15251.001Funded by
This work was funded by grants from the Spanish Ministry of Economy and Competitiveness (SAF2011-27330 to PM; and SAF2011-25834 and SAF 2014-55579-R to FS-M); grant INDISNET-S2011/BMD-2332 from the Comunidad de Madrid to PM and FS-M; Red Cardiovascular RD 12-0042-0056 from Instituto Salud Carlos III (ISCIII), and ERC-2011-AdG294340-GENTRIS to FS-M; and National Institutes of Health grant RO1 AR068383 to UHvA. OB is supported by a fellowship from Fundación Alfonso Martin Escudero, ERC and RO1 grants. DC is supported by SAF grant.Project
Gobierno de España. SAF2011-27330; Gobierno de España. SAF2011-25834; Gobierno de España. SAF2014-55579-R; Comunidad de Madrid. S2011/BMD-2332/INDISNETEditor's Version
http://dx.doi.org/10.7554/eLife.15251Subjects
Skin-resident; Murine dermal perivascular; Macrophages; Endothelial junctions; Blood-borne macromolecule; MedicinaRights
© Barreiro et al.Abstract
Heterogeneity and functional specialization among skin-resident macrophages are
incompletely understood. In this study, we describe a novel subset of murine dermal perivascular
macrophages that extend protrusions across the endothelial junctions in steady-state and capture
blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by
bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an
extramedullary radio-resistant and UV-sensitive Bmi1+ progenitor. Furthermore, they possess a
distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory
conditions, and are involved in repair and remodeling functions for which other skin-resident
macrophages appear dispensable. Based on all their properties, we define these macrophages as
Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that
their preservation is important for skin homeostasis
Files in this item
Google Scholar:Barreiro, Olga
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Cibrian, Danay
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Clement, Cristina
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Álvarez, David
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Moreno, Vanessa
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Valiente, Íñigo
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Bernad, Antonio
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Vestweber, Dietmar
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Arroyo, Alicia G.
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Martín, Pilar
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Andrian, Ulrich H von
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Sánchez Madrid, Francisco
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