Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

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dc.contributor.author Barreiro, Olga
dc.contributor.author Cibrian, Danay
dc.contributor.author Clement, Cristina
dc.contributor.author Álvarez, David
dc.contributor.author Moreno, Vanessa
dc.contributor.author Valiente, Íñigo
dc.contributor.author Bernad, Antonio
dc.contributor.author Vestweber, Dietmar
dc.contributor.author Arroyo, Alicia G.
dc.contributor.author Martín, Pilar
dc.contributor.author Andrian, Ulrich H von
dc.contributor.author Sánchez Madrid, Francisco
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP) es_ES
dc.date.accessioned 2017-04-27T13:25:26Z
dc.date.available 2017-04-27T13:25:26Z
dc.date.issued 2016-06-15
dc.identifier.citation eLife 5 (2016): e15251 es_ES
dc.identifier.issn 2050-084X es_ES
dc.identifier.uri http://hdl.handle.net/10486/678048
dc.description.abstract Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1+ progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis en_US
dc.description.sponsorship This work was funded by grants from the Spanish Ministry of Economy and Competitiveness (SAF2011-27330 to PM; and SAF2011-25834 and SAF 2014-55579-R to FS-M); grant INDISNET-S2011/BMD-2332 from the Comunidad de Madrid to PM and FS-M; Red Cardiovascular RD 12-0042-0056 from Instituto Salud Carlos III (ISCIII), and ERC-2011-AdG294340-GENTRIS to FS-M; and National Institutes of Health grant RO1 AR068383 to UHvA. OB is supported by a fellowship from Fundación Alfonso Martin Escudero, ERC and RO1 grants. DC is supported by SAF grant. en_US
dc.format.extent 33 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher eLife Sciences Publications Ltd en_US
dc.relation.ispartof eLife en_US
dc.rights © Barreiro et al. es_ES
dc.subject.other Skin-resident en_US
dc.subject.other Murine dermal perivascular en_US
dc.subject.other Macrophages en_US
dc.subject.other Endothelial junctions en_US
dc.subject.other Blood-borne macromolecule en_US
dc.title Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.7554/eLife.15251 es_ES
dc.identifier.doi 10.7554/eLife.15251.001 es_ES
dc.identifier.publicationfirstpage e15251-1 es_ES
dc.identifier.publicationissue 5 es_ES
dc.identifier.publicationlastpage e15251-33 es_ES
dc.relation.projectID Gobierno de España. SAF2011-27330 es_ES
dc.relation.projectID Gobierno de España. SAF2011-25834 es_ES
dc.relation.projectID Gobierno de España. SAF2014-55579-R es_ES
dc.relation.projectID Comunidad de Madrid. S2011/BMD-2332/INDISNET es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Sánchez Madrid, Francisco (259404)


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