Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices

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dc.contributor.author Punzón, Eva
dc.contributor.author García-Alvarado, Fernanda
dc.contributor.author Maroto, Marcos
dc.contributor.author Fernández-Mendívil, Cristina
dc.contributor.author Michalska, Patrycja
dc.contributor.author García-Álvarez, Isabel
dc.contributor.author Arranz-Tagarro, Juan Alberto
dc.contributor.author Buendía, Izaskun
dc.contributor.author López, Mauela G.
dc.contributor.author León, Rafael
dc.contributor.author Gandía, Luis
dc.contributor.author Fernández-Mayoralas, Alfonso
dc.contributor.author García, Antonio G.
dc.contributor.other UAM. Departamento de Farmacología es_ES
dc.date.accessioned 2017-05-23T11:22:10Z
dc.date.available 2017-05-23T11:22:10Z
dc.date.issued 2017-04-01
dc.identifier.citation Neuropharmacology 116 (2017): 110-121 en_US
dc.identifier.issn 0028-3908 (print) en_US
dc.identifier.issn 1873-7064 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/678276
dc.description Los datos de investigación asociados a este artículo están disponibles en http://dx.doi.org/10.1016/j.neuropharm.2016.12.016 es_ES
dc.description.abstract Compound IG20 is a newly synthesised sulphated glycolipid that promotes neuritic outgrowth and myelinisation, at the time it causes the inhibition of glial proliferation and facilitates exocytosis in chromaffin cells. Here we have shown that IG20 at 0.3–10 μM afforded neuroprotection in rat hippocampal slices stressed with veratridine, glutamate or with oxygen plus glucose deprivation followed by reoxygenation (OGD/reox). Excess production of reactive oxygen species (ROS) elicited by glutamate or ODG/reox was prevented by IG20 that also restored the depressed tissue levels of GSH and ATP in hippocampal slices subjected to OGD/reox. Furthermore, the augmented iNOS expression produced upon OGD/reox exposure was also counteracted by IG20. Additionally, the IG20 elicited neuroprotection was prevented by the presence of inhibitors of the signalling pathways Jak2/STAT3, MEK/ERK1/2, and PI3K/Akt, consistent with the ability of the compound to increase the phosphorylation of Jak2, ERK1/2, and Akt. Thus, the activation of phase II response and the Nrf2/ARE pathway could explain the antioxidant and anti-inflammatory effects and the ensuing neuroprotective actions of IG20 en_US
dc.description.sponsorship This study was supported by a grant from Ministerio de Economía y Competitividad, Spain (MINECO SAF2013-44108-P to AGG and LG; MAT2015-65184-C2-2-R to AFM, CABICYC UAM-Bioiberica and European Commission-ERC, People (Marie Curie Actions) FP7 under REA grant agreement n PCIG11-GA-2012-322156; Spanish Ministry of Health (Instituto de Salud Carlos III) (grant PI14/00372) and Miguel Servet (CP11/00165); Bayer A.G., “From Targets to Novel Drugs” program (grant 2015-03-1282) and Fundacion FIPSE (grant 12-00001344-15) to RL. RL thanks IS Carlos III for research contract under Miguel Servet Program. P.M. thanks MECD for FPU fellowship (AP2010-1219) en_US
dc.format.extent 40 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Elsevier en_US
dc.relation.ispartof Neuropharmacology en_US
dc.rights © 2016 Elsevier Ltd. es_ES
dc.subject.other Hippocampal neurons en_US
dc.subject.other Hippocampal slices en_US
dc.subject.other Neuronal excitability en_US
dc.subject.other Neuroprotection en_US
dc.subject.other Neurotoxicity en_US
dc.subject.other Oxidative stress en_US
dc.subject.other Sulfoglycolipid IG20 en_US
dc.title Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices en_US
dc.type article en_US
dc.subject.eciencia Medicina es_ES
dc.date.embargoend 2017-12-20
dc.relation.publisherversion https://doi.org/10.1016/j.neuropharm.2016.12.016 es_ES
dc.identifier.doi 10.1016/j.neuropharm.2016.12.016 es_ES
dc.identifier.publicationfirstpage 110 es_ES
dc.identifier.publicationissue 116 es_ES
dc.identifier.publicationlastpage 121 es_ES
dc.relation.projectID Gobierno de España. SAF2013-44108 es_ES
dc.relation.projectID Gobierno de España. MAT2015-65184-C2-2-R es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/322156 en
dc.type.version info:eu-repo/semantics/acceptedVersion en
dc.rights.cc Reconocimiento – NoComercial – SinObraDerivada es_ES
dc.rights.accessRights openAccess en
dc.authorUAM León Martínez, Rafael (264118)


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