Use of proton-pump inhibitors predicts heart failure and death in patients with coronary artery disease

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dc.contributor.author Pello, Ana María
dc.contributor.author Cristóbal, Carmen
dc.contributor.author Franco-Peláez, Juan Antonio
dc.contributor.author Tarín, Nieves
dc.contributor.author Aceña, Álvaro
dc.contributor.author Carda, Rocío
dc.contributor.author Huelmos, Ana
dc.contributor.author Martín-Mariscal, María Luisa
dc.contributor.author Fuentes-Antras, Jesús
dc.contributor.author Martínez-Milla, Juan
dc.contributor.author Alonso, Joaquín
dc.contributor.author Lorenzo, Óscar
dc.contributor.author Egido, Jesús
dc.contributor.author López-Bescós, Lorenzo
dc.contributor.author Tuñón, José
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) es_ES
dc.date.accessioned 2017-07-18T14:37:56Z
dc.date.available 2017-07-18T14:37:56Z
dc.date.issued 2017-01-19
dc.identifier.citation PLoS ONE 12.1 (2017): e0169826 en_US
dc.identifier.issn 1932-6203 es_ES
dc.identifier.uri http://hdl.handle.net/10486/679056
dc.description.abstract Proton-pump inhibitors (PPIs) seem to increase the incidence of cardiovascular events in patients with coronary artery disease (CAD), mainly in those using clopidogrel. We analysed the impact of PPIs on the prognosis of patients with stable CAD. Methods We followed 706 patients with CAD. Primary outcome was the combination of secondary outcomes. Secondary outcomes were 1) acute ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and 2) heart failure (HF) or death. Results Patients on PPIs were older [62.0 (53.0±73.0) vs. 58.0 (50.0±70.0) years; p = 0.003] and had a more frequent history of stroke (4.9% vs. 1.1%; p = 0.004) than those from the non- PPI group, and presented no differences in any other clinical variable, including cardiovascular risk factors, ejection fraction, and therapy with aspirin and clopidogrel. Follow-up was 2.2±0.99 years. Seventy-eight patients met the primary outcome, 53 developed acute ischaemic events, and 33 HF or death. PPI use was an independent predictor of the primary outcome [hazard ratio (HR) = 2.281 (1.244±4.183); p = 0.008], along with hypertension, body-mass index, glomerular filtration rate, atrial fibrillation, and nitrate use. PPI use was also an independent predictor of HF/death [HR = 5.713 (1.628±20.043); p = 0.007], but not of acute ischaemic events. A propensity score showed similar results. Conclusions In patients with CAD, PPI use is independently associated with an increased incidence of HF and death but not with a high rate of acute ischaemic events. Further studies are needed to confirm these findings en_US
dc.description.sponsorship This work was supported by grants from Fondo de Investigaciones Sanitarias [grant numbers PI 14/1567, PI13/00047, PIE13/00051], ISCIII-RETIC REDinREN RD12/0021, Comunidad de Madrid [sGEN/0247/2006, S2010/BMD-2378], Spanish Society of Cardiology; Spanish Heart Foundation; RECAVA [grant number RD06/0014/0035]; Instituto de Salud Carlos III FEDER [FJD biobank grant number RD09/0076/00101] en_US
dc.format.extent 13 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Public Library of Science en_US
dc.relation.ispartof PLoS ONE en_US
dc.rights © 2017 Pello Lázaro et al. es_ES
dc.subject.other Proton.pump inhibitors en_US
dc.subject.other Patients en_US
dc.subject.other Coronary artery disease es_ES
dc.subject.other Heart failure en_US
dc.subject.other Death en_US
dc.title Use of proton-pump inhibitors predicts heart failure and death in patients with coronary artery disease en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1371/ journal.pone.0169826 es_ES
dc.identifier.doi 10.1371/ journal.pone.0169826 es_ES
dc.identifier.publicationfirstpage e0169826-1 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage e0169826-13 es_ES
dc.identifier.publicationvolume 12 es_ES
dc.relation.projectID Comunidad de Madrid. sGEN/0247/2006 es_ES
dc.relation.projectID Comunidad de Madrid. S2010/BMD-2378/CIFRA es_ES
dc.relation.projectID Gobierno de España. PI14/1567 es_ES
dc.relation.projectID Gobierno de España. PI13/00047 es_ES
dc.relation.projectID Gobierno de España. PIE13/00051 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Aceña Navarro, Álvaro (279732)
dc.authorUAM Tuñón Fernández, José Luis (258858)


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