Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study

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Show simple item record Huerta, José M. Chirlaque, María Dolores Molina, Antonio J. Amiano, Pilar Martín, Vicente Fernández-Villa, Tania Pérez-Gómez, Beatriz Moreno, Víctor Burgui, Rosana Gómez-Acebo, Inés Ramos-Lora, Manuel Fernández-Tardón, Guillermo Peiró, Rosana Olmedo-Requena, Rocío Pollán, Marina Kogevinas, Manolis Castaño-Vinyals, Gemma Aragonés, Nuria Navarro
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES 2017-11-06T16:25:29Z 2017-11-06T16:25:29Z 2017-07-01
dc.identifier.citation PLoS Genetics 13.7 (2017): e0179731 en_US
dc.identifier.issn 1932-6203 es_ES
dc.description.abstract This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. Methods: 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals’ catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse). Results: Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants. Conclusions: Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study. en_US
dc.description.sponsorship The study was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundación Marqués de Valdecilla (API 10/09), the Junta de Castilla y León (LE22A10±2), the Consejería de Salud of the Junta de Andalucía (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional Government of the Basque Country, the Consejería de Sanidad de la Región de Murcia, the European Commission grants FOOD-CT-2006±036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the Catalan Government DURSI grant 2014SGR647, the Fundación Caja de Ahorros de Asturias and by the University of Oviedo en_US
dc.format.extent 16 pag. es_ES
dc.format.mimetype application/pdf en_US
dc.language.iso eng en
dc.publisher Public Library of Science en_US
dc.relation.ispartof PLos One en_US
dc.rights © 2017 Huerta et al. es_ES
dc.subject.other Association of domain-specific physical activity en_US
dc.subject.other Risk of gastric adenocarcinoma en_US
dc.subject.other Highest HPA category en_US
dc.subject.other MCC-Spain study en_US
dc.title Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion es_ES
dc.identifier.doi 10.1371/journal.pone.0179731 es_ES
dc.identifier.publicationfirstpage e0179731-1 es_ES
dc.identifier.publicationissue 7 es_ES
dc.identifier.publicationlastpage e0179731-16 es_ES
dc.identifier.publicationvolume 12 es_ES
dc.relation.projectID Gobierno de España. PI08/1359 es_ES
dc.relation.projectID Gobierno de España. PI09/00773 es_ES
dc.relation.projectID Gobierno de España. PI09/01286 es_ES
dc.relation.projectID Gobierno de España. PI09/01903 es_ES
dc.relation.projectID Gobierno de España. PI09/02078 es_ES
dc.relation.projectID Gobierno de España. PI09/01662 es_ES
dc.relation.projectID Gobierno de España. PI11/01403 es_ES
dc.relation.projectID Gobierno de España. PI11/01889 es_ES
dc.relation.projectID Gobierno de España. PI12/00265 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/036224 en
dc.type.version info:eu-repo/semantics/publishedVersion en Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Pollán Santamaría, Marina Anunciación (262007)

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