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dc.contributor.authorHuerta, José M.
dc.contributor.authorChirlaque, María Dolores
dc.contributor.authorMolina, Antonio J.
dc.contributor.authorAmiano, Pilar
dc.contributor.authorMartín, Vicente
dc.contributor.authorFernández-Villa, Tania
dc.contributor.authorPérez-Gómez, Beatriz
dc.contributor.authorMoreno, Víctor
dc.contributor.authorBurgui, Rosana
dc.contributor.authorGómez-Acebo, Inés
dc.contributor.authorRamos-Lora, Manuel
dc.contributor.authorFernández-Tardón, Guillermo
dc.contributor.authorPeiró, Rosana
dc.contributor.authorOlmedo-Requena, Rocío
dc.contributor.authorPollán Santamaría, Marina Anunciación 
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorAragonés, Nuria
dc.contributor.authorNavarro
dc.contributor.otherUAM. Departamento de Medicina Preventiva y Salud Pública y Microbiologíaes_ES
dc.date.accessioned2017-11-06T16:25:29Z
dc.date.available2017-11-06T16:25:29Z
dc.date.issued2017-07-01
dc.identifier.citationPLoS Genetics 13.7 (2017): e0179731en_US
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/10486/680144
dc.description.abstractThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. Methods: 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals’ catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse). Results: Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants. Conclusions: Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.en_US
dc.description.sponsorshipThe study was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundación Marqués de Valdecilla (API 10/09), the Junta de Castilla y León (LE22A10±2), the Consejería de Salud of the Junta de Andalucía (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional Government of the Basque Country, the Consejería de Sanidad de la Región de Murcia, the European Commission grants FOOD-CT-2006±036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the Catalan Government DURSI grant 2014SGR647, the Fundación Caja de Ahorros de Asturias and by the University of Oviedoen_US
dc.format.extent16 pag.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLos Oneen_US
dc.rights© 2017 Huerta et al.es_ES
dc.subject.otherAssociation of domain-specific physical activityen_US
dc.subject.otherRisk of gastric adenocarcinomaen_US
dc.subject.otherHighest HPA categoryen_US
dc.subject.otherMCC-Spain studyen_US
dc.titlePhysical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control studyen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0179731es_ES
dc.identifier.doi10.1371/journal.pone.0179731es_ES
dc.identifier.publicationfirstpagee0179731-1es_ES
dc.identifier.publicationissue7es_ES
dc.identifier.publicationlastpagee0179731-16es_ES
dc.identifier.publicationvolume12es_ES
dc.relation.projectIDGobierno de España. PI08/1359es_ES
dc.relation.projectIDGobierno de España. PI09/00773es_ES
dc.relation.projectIDGobierno de España. PI09/01286es_ES
dc.relation.projectIDGobierno de España. PI09/01903es_ES
dc.relation.projectIDGobierno de España. PI09/02078es_ES
dc.relation.projectIDGobierno de España. PI09/01662es_ES
dc.relation.projectIDGobierno de España. PI11/01403es_ES
dc.relation.projectIDGobierno de España. PI11/01889es_ES
dc.relation.projectIDGobierno de España. PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/036224en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMPollán Santamaría, Marina Anunciación (262007)
dc.facultadUAMFacultad de Medicina


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