EUDOR-A multi-centre research program: A naturalistic, European Multi-centre Clinical study of EDOR Test in adult patients with primary depression

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dc.contributor.author Sarchiapone, Marco
dc.contributor.author Iosue, Miriam
dc.contributor.author Carli, Vladimir
dc.contributor.author Amore, Mario
dc.contributor.author Baca García, Enrique
dc.contributor.author Batra, Anil
dc.contributor.author Cosman, Doina
dc.contributor.author Courtet, Philippe
dc.contributor.author Di Sciascio, Guido
dc.contributor.author Gusmao, Ricardo
dc.contributor.author Parnowski, Tadeusz
dc.contributor.author Pestality, Peter
dc.contributor.author Saiz, Pilar
dc.contributor.author Thome, Johannes
dc.contributor.author Tingström, Anders
dc.contributor.author Wojnar, Marcin
dc.contributor.author Zeppegno, Patrizia
dc.contributor.author Thorell, Lars Håkan
dc.contributor.other UAM. Departamento de Psiquiatría es_ES
dc.contributor.other Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) es_ES
dc.date.accessioned 2017-11-27T13:43:19Z
dc.date.available 2017-11-27T13:43:19Z
dc.date.issued 2017-03-23
dc.identifier.citation BMC Psychiatry 17.1 (2017): 108 en_US
dc.identifier.issn 1471-244X es_ES
dc.identifier.uri http://hdl.handle.net/10486/680492
dc.description.abstract Background: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide. The aims of the present study are to test the effectiveness and the usefulness of the EDOR (ElectroDermal Orienting Reactivity) Test as a support in the suicide risk assessment of depressed patients and to assess the predictive value of electrodermal hyporeactivity, measured through the EDOR Test, for suicide and suicide attempt in adult patients with a primary diagnosis of depression. Methods and design: 1573 patients with a primary diagnosis of depression, whether currently depressed or in remission, have been recruited at 15 centres in 9 different European countries. Depressive symptomatology was evaluated through the Montgomery-Asberg Depression Scale. Previous suicide attempts were registered and the suicide intent of the worst attempt was rated according to the first eight items of the Beck Suicide Intent Scale. The suicide risk was also assessed according to rules and traditions at the centre. The EDOR Test was finally performed. During the EDOR Test, two fingers are put on gold electrodes and direct current of 0.5 V is passed through the epidermis of the fingers according to standards. A moderately strong tone is presented through headphones now and then during the test. The electrodermal responses to the stimuli represent an increase in the conductance due to the increased number of filled sweat ducts that act as conductors through the electrically highly resistant epidermis. Each patient is followed up for one year in order to assess the occurrence of intentional self-harm. Discussion: Based on previous studies, expected results would be that patients realizing a suicide attempt with a strong intent or committing suicide should be electrodermally hyporeactive in most cases and non-hyporeactive patients should show only few indications of death intent or suicides. Trial registration: The German Clinical Trials Register, DRKS00010082. Registered May 31 st , 2016. Retrospectively registered. en_US
dc.description.sponsorship The EUDOR-A study was promoted and funded by EMOTRA AB, Sweden. en_US
dc.format.extent 9 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher BioMed Central Ltd. en_US
dc.relation.ispartof BMC Psychiatry en_:US
dc.rights © 2017 The Author(s) en_US
dc.subject.other Depression en_US
dc.subject.other Electrodermal hyporeactivity en_US
dc.subject.other Intentional self-harm en_US
dc.subject.other Skin conductance en_US
dc.subject.other Suicidal behaviour en_US
dc.subject.other Suicide en_US
dc.title EUDOR-A multi-centre research program: A naturalistic, European Multi-centre Clinical study of EDOR Test in adult patients with primary depression en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1186/s12888-017-1246-x es_ES
dc.identifier.doi 10.1186/s12888-017-1246-x es_ES
dc.identifier.publicationfirstpage 108-1 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 108-9 es_ES
dc.identifier.publicationvolume 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM Baca García, Enrique (261227)


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