The impact of obesity in the cardiac lipidomic and its consequences in the cardiac damage observed in obese rats
Title (trans.)
El impacto de la obesidad sobre el lipidoma cardíaco y sus consecuencias en el daño cardíaco en ratas obesasEntity
UAM. Departamento de FarmacologíaPublisher
ElsevierDate
2017-08-30Citation
10.1016/j.arteri.2017.07.004
Clínica e Investigación en Arteriosclerosis 30.1 (2018): 10-20
ISSN
0214-9168 (print); 1578-1879 (online)DOI
10.1016/j.arteri.2017.07.004Funded by
This work was supported by funds from the Sociedad Española de Arteriosclerosis (Basic Research Award 2015), from Plan Estatal I+D+I 2013-2016: PI15/01060 and SAF2016-81063. The study was cofunded by Fondo Europeo de Desarrollo Regional (FEDER), a way to build EuropeProject
Gobierno de España. SAF2016-81063; Gobierno de España. PI15/01060Editor's Version
https://doi.org/10.1016/j.arteri.2017.07.004Subjects
Cardiac remodeling; Fibrosis; Lipid profiling; Obesity; MedicinaRights
© 2017 Sociedad Española de ArteriosclerosisEsta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Abstract
To explore the impact of obesity on the cardiac lipid profile in rats with diet-induced obesity, as well as to evaluate whether or not the specific changes in lipid species are associated with cardiac fibrosis. Methods: Male Wistar rats were fed either a high-fat diet (HFD, 35% fat) or standard diet (3.5% fat) for 6 weeks. Cardiac lipids were analyzed using by liquid chromatography-tandem mass spectrometry. Results: HFD rats showed cardiac fibrosis and enhanced levels of cardiac superoxide anion (O 2 ), HOMA index, adiposity, and plasma leptin, as well as a reduction in those of cardiac glucose transporter (GLUT 4), compared with control animals. Cardiac lipid profile analysis showed a significant increase in triglycerides, especially those enriched with palmitic, stearic, and arachidonic acid. An increase in levels of diacylglycerol (DAG) was also observed. No changes in cardiac levels of diacyl phosphatidylcholine, or even a reduction in total levels of diacyl phosphatidylethanolamine, diacyl phosphatidylinositol, and sphingomyelins (SM) was observed in HFD, as compared with control animals. After adjustment for other variables (oxidative stress, HOMA, cardiac hypertrophy), total levels of DAG were independent predictors of cardiac fibrosis while the levels of total SM were independent predictors of the cardiac levels of GLUT 4. Conclusions: These data suggest that obesity has a significant impact on cardiac lipid composition, although it does not modulate the different species in a similar manner. Nonetheless, these changes are likely to participate in the cardiac damage in the context of obesity, since total DAG levels can facilitate the development of cardiac fibrosis, and SM levels predict GLUT4 levels
Files in this item
Google Scholar:Marín-Royo, Gema
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Martínez-Martínez, Ernesto
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Gutiérrez, Beatriz
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Jurado-López, Raquel
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Gallardo, Isabel
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Montero, Olimpio
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Bartolomé, Ma Visitación
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Román, José Alberto San
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Salaices Sánchez, Mercedes
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Nieto, María Luisa
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Cachofeiro, Victoria
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