Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Comparison of risk classification between EndoPredict and MammaPrint in ER-positive/HER2-negative primary invasive breast cancer
Entity
UAM. Departamento de Anatomía, Histología y Neurociencia; UAM. Departamento de Medicina; UAM. Departamento de Obstetricia y Ginecología; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
Public Library of ScienceDate
2017-09-08Citation
10.1371/journal.pone.0183452
PLoS ONE 12.9 (2017): e0183452
ISSN
1932-6203DOI
10.1371/journal.pone.0183452Funded by
The study was supported by the company Myriad Genetic España SLU.Editor's Version
https://doi.org/10.1371/journal.pone.0183452Subjects
EndoPredict; MammaPrint; Cancer; Breast carcinoma; Clinicopathological parameters; MedicinaRights
© 2017 Peláez GarcíaAbstract
Purpose: To compare the concordance in risk classification between the EndoPredict and the MammaPrint scores obtained for the same cancer samples on 40 estrogen-receptor positive/ HER2-negative breast carcinomas. Methods: Formalin-fixed, paraffin-embedded invasive breast carcinoma tissues that were previously analyzed with MammaPrint as part of routine care of the patients, and were classified as high-risk (20 patients) and low-risk (20 patients), were selected to be analyzed by the EndoPredict assay, a second generation gene expression test that combines expression of 8 genes (EP score) with two clinicopathological variables (tumor size and nodal status, EPclin score). Results: The EP score classified 15 patients as low-risk and 25 patients as high-risk. EPclin re-classified 5 of the 25 EP high-risk patients into low-risk, resulting in a total of 20 high-risk and 20 low-risk tumors. EP score and MammaPrint score were significantly correlated (p = 0.008). Twelve of 20 samples classified as low-risk by MammaPrint were also low-risk by EP score (60%). 17 of 20 MammaPrint high-risk tumors were also high-risk by EP score. The overall concordance between EP score and MammaPrint was 72.5% (κ = 0.45, (95% CI, 0.182 to 0.718)). EPclin score also correlated with MammaPrint results (p = 0.004). Discrepancies between both tests occurred in 10 cases: 5 MammaPrint low-risk patients were classified as EPclin high-risk and 5 high-risk MammaPrint were classified as low-risk by EPclin and overall concordance of 75% (κ = 0.5, (95% CI, 0.232 to 0.768)). Conclusions: This pilot study demonstrates a limited concordance between MammaPrint and EndoPredict. Differences in results could be explained by the inclusion of different gene sets in each platform, the use of different methodology, and the inclusion of clinicopathological parameters, such as tumor size and nodal status, in the EndoPredict test.
Files in this item
Google Scholar:Peláez-García, Alberto
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Yébenes, Laura
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Berjón, Alberto
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Angulo, Antonia
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Zamora, Pilar
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Sánchez Méndez, José Ignacio
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Espinosa Arranz, Enrique
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Redondo Sánchez, Andrés
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Heredia-Soto, Victoria
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Mendioala, Marta
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Feliú Batlle, Jaime
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Hardisson Hernáez, David Alonso
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