The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer

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dc.contributor.author Fernández, Lara P.
dc.contributor.author Ramos-Ruiz, Ricardo
dc.contributor.author Herranz, Jesús
dc.contributor.author Martín-Hernández, Roberto
dc.contributor.author Vargas, Teodoro
dc.contributor.author Mendiola, Marta
dc.contributor.author Guerra, Laura
dc.contributor.author Reglero, Guillermo
dc.contributor.author Feliu, Jaime
dc.contributor.author Ramírez de Molina, Ana
dc.contributor.other UAM. Departamento de Ecología es_ES
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other UAM. Departamento de Química Física Aplicada es_ES
dc.date.accessioned 2018-04-04T12:55:13Z
dc.date.available 2018-04-04T12:55:13Z
dc.date.issued 2018-01-01
dc.identifier.citation Oncotarget 9.5 (2018): 5919-5930 en_US
dc.identifier.issn 1949-2553 es_ES
dc.identifier.uri http://hdl.handle.net/10486/681595
dc.description.abstract Metabolic alterations encountered in tumors are well recognized and considered as a hallmark of cancer. In addition to Warburg Effect, epidemiological and experimental studies support the crucial role of lipid metabolism in colorectal cancer (CRC). The overexpression of four lipid metabolism-related genes (ABCA1, ACSL1, AGPAT1 and SCD genes) has been proposed as prognostic marker of stage II CRC (ColoLipidGene signature). In order to explore in depth the transcriptomic and genomic scenarios of ABCA1, ACSL1, AGPAT1 and SCD genes, we performed a transcriptomic meta-analysis in more than one thousand CRC individuals. Additionally we analyzed their genomic coding sequence in 95 patients, to find variants that could orchestrate CRC prognosis. We found that genetic variant rs3071, located on SCD gene, defines a 9.77% of stage II CRC patients with high risk of death. Moreover, individuals with upregulation of ABCA1 and AGPAT1 expression have an increased risk of CRC recurrence, independently of tumor stage. ABCA1 emerges as one of the main contributors to signature's prognostic effect. Indeed, both high ABCA1 expression and presence of tumoral genetic variants located in ABCA1 coding region, seem to be associated with CRC risk of death. In addition the non-synonymous polymorphism rs2230808, located on ABCA1, is associated with gene expression. Patients carrying at least one copy of minor allele showed higher levels of ABCA1 expression than patients carrying homozygous major allele. This study broaden the prognostic value of ABCA1, ACSL1, AGPAT1 and SCD genes, independently of CRC tumor stage, leading to future precision medicine approaches and "omics"-guided therapies en_US
dc.description.sponsorship Ministerio de Economía y Competitividad del Gobierno de España (MINECO, Plan Nacional I+D+i AGL2016-76736-C3), Gobierno regional de la Comunidad de Madrid (P2013/ABI-2728, ALIBIRD-CM) and EU Structural Funds es_ES
dc.format.extent 12 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Impact Journals en_US
dc.relation.ispartof Oncotarget en_US
dc.rights © 2018 Fernández et al. es_ES
dc.subject.other Colorectal cancer en_US
dc.subject.other Gene expression profile en_US
dc.subject.other Genetic variations en_US
dc.subject.other Lipid metabolism en_US
dc.subject.other Prognosis en_US
dc.title The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer en_US
dc.type article en
dc.subject.eciencia Ciencia y Tecnología de Alimentos es_ES
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.18632/oncotarget.23592 es_ES
dc.identifier.doi 10.18632/oncotarget.23592 es_ES
dc.identifier.publicationfirstpage 5919 es_ES
dc.identifier.publicationissue 5 es_ES
dc.identifier.publicationlastpage 5930 es_ES
dc.identifier.publicationvolume 9 es_ES
dc.relation.projectID Gobierno de España. AGL2016-76736-C3 es_ES
dc.relation.projectID Comunidad de Madrid. P2013/ABI-2728/ALIBIRD-CM es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Herranz Barrera, Jesús (260466)


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