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Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: Cytotoxicity, solution behaviour and interaction: Versus proven models from biological media

dc.contributor.authorMatesanz García, Ana Isabel 
dc.contributor.authorJimenez-Faraco, Eva
dc.contributor.authorRuiz, María C.
dc.contributor.authorBalsa, Lucia M.
dc.contributor.authorNavarro-Ranninger, Carmen
dc.contributor.authorLeón, Ignacio E.
dc.contributor.authorGómez Quiroga, Adoración 
dc.contributor.otherUAM. Departamento de Química Inorgánicaes_ES
dc.date.accessioned2018-04-23T16:08:25Z
dc.date.available2018-04-23T16:08:25Z
dc.date.issued2018-01-01
dc.identifier.citationInorganic Chemistry Frontiers 5.1 (2018): 73-83en_US
dc.identifier.issn2052-1553es_ES
dc.identifier.urihttp://hdl.handle.net/10486/681764
dc.description.abstractTwo Pd(ii) and Pt(ii) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(ii) compound shows a higher antitumor activity and selectivity than the Pt(ii) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(ii) complex is a more interesting candidate for potential anticancer therapies than the Pt(ii) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.en_US
dc.description.sponsorshipThis work was supported by the following grants for the Spanish MINECO: SAF-2012-34424, CTQ2015-68779R and CTQ2015-70371-REDTen_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherRoyal of Society of Chemistryen_US
dc.relation.ispartofInorganic Chemistry Frontiersen_US
dc.rights© 2017 The Royal Society of Chemistryen_US
dc.subject.otherMononuclear structuresen_US
dc.subject.otherTumor cellsen_US
dc.subject.otherAntitumor activityen_US
dc.subject.otherPd(II) complexen_US
dc.subject.otherPotential anticancer therapiesen_US
dc.titleMononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: Cytotoxicity, solution behaviour and interaction: Versus proven models from biological mediaen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.date.embargoend2019-01-01
dc.relation.publisherversionhttp://doi.org/10.1039/C7QI00446Jes_ES
dc.identifier.doi10.1039/C7QI00446Jes_ES
dc.identifier.publicationfirstpage73es_ES
dc.identifier.publicationissue1es_ES
dc.identifier.publicationlastpage83es_ES
dc.identifier.publicationvolume5es_ES
dc.relation.projectIDGobierno de España. SAF-2012-34424es_ES
dc.relation.projectIDGobierno de España. CTQ2015-68779Res_ES
dc.relation.projectIDGobierno de España. CTQ2015-70371-REDTes_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Ciencias


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