dc.contributor.author | Gómez, Rosa M. | |
dc.contributor.author | Sánchez, Magdy Y. | |
dc.contributor.author | Portela-Lomba, María | |
dc.contributor.author | Ghotme, Kemel | |
dc.contributor.author | Barreto, George E. | |
dc.contributor.author | Sierra, Javier | |
dc.contributor.author | Moreno-Flores, M. Teresa | |
dc.contributor.other | UAM. Departamento de Anatomía, Histología y Neurociencia | es_ES |
dc.date.accessioned | 2018-05-23T13:00:24Z | |
dc.date.available | 2018-05-23T13:00:24Z | |
dc.date.issued | 2018-01-13 | |
dc.identifier.citation | GLIA 13 January (2018): 1-35 | es_ES |
dc.identifier.issn | 0894-1491 (print) | es_ES |
dc.identifier.issn | 1098-1136 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/682490 | |
dc.description | This is the peer reviewed version of the following article: Gómez RM, Sánchez MY, Portela-Lomba M, et al. Cell therapy for spinal cord injury with olfactoryensheathing glia cells (OECs). Glia. 2018;00:1–35
which has been published in final form at GLIA 13 January (2018) http://doi.org/10.1002/glia.23282. © 2018 Wiley Periodicals This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.description.abstract | The prospects of achieving regeneration in the central nervous system (CNS) have changed, asmost recent findings indicate that several species, including humans, can produce neurons in adult-hood. Studies targeting this property may be considered as potential therapeutic strategies torespond to injury or the effects of demyelinating diseases in the CNS. While CNS trauma mayinterrupt the axonal tracts that connect neurons with their targets, some neurons remain alive, asseen in optic nerve and spinal cord (SC) injuries (SCIs). The devastating consequences of SCIs aredue to the immediate and significant disruption of the ascending and descending spinal pathways,which result in varying degrees of motor and sensory impairment. Recent therapeutic studies forSCI have focused on cell transplantation in animal models, using cells capable of inducing axonregeneration like Schwann cells (SchCs), astrocytes, genetically modified fibroblasts and olfactoryensheathing glia cells (OECs). Nevertheless, and despite the improvements in such cell-based ther-apeutic strategies, there is still little information regarding the mechanisms underlying the successof transplantation and regarding any secondary effects. Therefore, further studies are needed to clarify these issues. In this review, we highlight the properties of OECs that make them suitable toachieve neuroplasticity/neuroregeneration in SCI. OECs can interact with the glial scar, stimulateangiogenesis, axon outgrowth and remyelination, improving functional outcomes following lesion.Furthermore, we present evidence of the utility of cell therapy with OECs to treat SCI, both fromanimal models and clinical studies performed on SCI patients, providing promising results for future treatments. | en_US |
dc.format.extent | 102 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Wiley Periodicals | en_US |
dc.relation.ispartof | GLIA | es_ES |
dc.rights | © 2018 Wiley Periodicals | en_US |
dc.subject.other | Cell therapies | en_US |
dc.subject.other | Cell transplantation | en_US |
dc.subject.other | Neuroregeneration | en_US |
dc.subject.other | Olfactory ensheathing glia cells | en_US |
dc.subject.other | Spinal cord injuries | en_US |
dc.subject.other | Transplantation | en_US |
dc.title | Cell therapy for spinal cord injury with Olfactory Ensheathing Glia Cells (OECs) | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.date.embargoend | 2019-01-13 | |
dc.relation.publisherversion | http://doi.org/10.1002/glia.23282 | es_ES |
dc.identifier.doi | 10.1002/glia.23282 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationissue | x | es_ES |
dc.identifier.publicationlastpage | 35 | es_ES |
dc.identifier.publicationvolume | x | es_ES |
dc.type.version | info:eu-repo/semantics/acceptedVersion | en |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |