dc.contributor.author | Mas, Sebastián | |
dc.contributor.author | Bosch-Panadero, Enrique | |
dc.contributor.author | Abaigar, Pedro | |
dc.contributor.author | Camarero, Vanesa | |
dc.contributor.author | Mahillo, Ignacio | |
dc.contributor.author | Civantos, Esther | |
dc.contributor.author | Sanchez-Ospina, Didier | |
dc.contributor.author | Ruiz-Priego, Alberto | |
dc.contributor.author | Egido, Jesus | |
dc.contributor.author | Ortiz Arduán, Alberto | |
dc.contributor.author | González-Parra, Emilio | |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) | es_ES |
dc.date.accessioned | 2018-05-23T17:32:44Z | |
dc.date.available | 2018-05-23T17:32:44Z | |
dc.date.issued | 2018-03-01 | |
dc.identifier.citation | PLoS ONE 13.3 (2018): e0193288 | en_US |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/682504 | |
dc.description.abstract | Introduction: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. Methods A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron). Results After a run-in OL-HDF period of at least 6 months with the same membrane, baseline predialysis BPA was lower in patients on polynephron (8.79±7.97 ng/ml) than in those on polysulfone (23.42±20.38 ng/mL, p < 0.01), but still higher than in healthy controls ( < 2 ng/mL). After 3 months of polynephron-to-polysulfone switch, BPA was unchanged (8.98±7.88 to 11.14±15.98 ng/mL, ns) while it decreased on the polysulfone-to-polynephron group (23.42±20.38 to 11.41±12.38 ng/mL, p < 0.01). Conclusion OL-HDF for 3 months with BPA-free dialyzer membranes was associated to a significant decrease in predialysis BPA levels when compared to baseline BPA levels while on a BPA-containing membrane | en_US |
dc.description.sponsorship | The Renal, Vascular and Diabetes Laboratory is funded by Ministerio de Economia,
Industria y competitividad: FIS ISCIII FEDER funds PI16/01298, PI15/00298, PI16/02057, PI16/01900, SCIII-RETIC REDinREN RD12/0021 RD16/0009, CYTED IBERERC and Sociedad Madrileña de Nefrologia, Programa Intensificación Actividad Investigadora (ISCIII) to AO. This work was supported by a grant from Nipro corporation, and
Fundacioón Renal Íñigo Álvarez de Toledo (FRIAT) | en_US |
dc.format.extent | 11 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | es_ES |
dc.relation.ispartof | PLos ONE | es_ES |
dc.rights | © 2018 Mas et al. | es_ES |
dc.subject.other | Bisphenol A | en_US |
dc.subject.other | Online hemodiafiltration (OL-HDF) | en_US |
dc.subject.other | Dialysis membranes | en_US |
dc.title | Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0193288 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0193288 | es_ES |
dc.identifier.publicationfirstpage | e0193288-1 | es_ES |
dc.identifier.publicationissue | 3 | es_ES |
dc.identifier.publicationlastpage | e0193288-11 | es_ES |
dc.identifier.publicationvolume | 13 | es_ES |
dc.relation.projectID | Gobierno de España. PI16/01298 | es_ES |
dc.relation.projectID | Gobierno de España. PI15/00298 | es_ES |
dc.relation.projectID | Gobierno de España. PI16/02057 | es_ES |
dc.relation.projectID | Gobierno de España. PI16/01900 | es_ES |
dc.relation.projectID | Gobierno de España. RD12/0021 | es_ES |
dc.relation.projectID | Gobierno de España. RD16/0009 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) | |