Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
Entity
UAM. Departamento de Bioquímica; UAM. Departamento de Química Inorgánica; Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)Publisher
The Royal SocietyDate
2018-02-01Citation
10.1098/rsos.171340
Royal Society Open Science 5.2 (2018): 171340
ISSN
2054-5703DOI
10.1098/rsos.171340Funded by
This work was supported by Spanish MINECO: CTQ2015-68779R and CTQ2015-70371-REDTProject
Gobierno de España. CTQ2015-68779R; Gobierno de España. CTQ2015-70371-REDTEditor's Version
http://dx.doi.org/10.1098/rsos.171340Subjects
Cytotoxicity; Metallodrug; Platinum drugs and DNA; Protein interaction; Medicina; QuímicaRights
© 2018 The AuthorsAbstract
Three platinum complexes with cis and trans configuration cis-[Pt(TCEP) 2 Cl 2 ], cis-[Pt(tmTCEP) 2 Cl 2 ] and trans-[Pt(TCEP) 2 Cl 2 ], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP) 2 Cl 2 ] and cis-[Pt(tmTCEP) 2 Cl 2 ]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied.
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Google Scholar:Echeverri, Marcelo
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Álvarez-Valdés Olaguibel, María Desamparados
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Navas, Francisco
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Perles, Josefina
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Sánchez Pérez, María Isabel
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Quiroga, A. G.
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