Generation of a human iPSC line, IISHDOi002-A, with a 46, XY/47, XYY mosaicism and belonging to an African mitochondrial haplogroup
Entity
UAM. Departamento de Bioquímica; Centro de Biología Molecular Severo Ochoa (CBM)Publisher
ELsevierDate
2018-04-01Citation
10.1016/j.scr.2018.02.009
Stem Cell Research 28 (2018): 131-135
ISSN
1873-5061 (print); 1876-7753 (online)DOI
10.1016/j.scr.2018.02.009Funded by
This work was supported by grants from: 1) the “Fondo de Investigación Sanitaria, Instituto de Salud Carlos III”: PI10/0703, PI13/00556 and PI16/00789 to RG and PI15/00484 to MEG cofunded by FEDER, 2) from the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER): grants 13-717/132.05 and ER16P3AC717 to RG and 3) “Comunidad Autónoma de Madrid” (grant number S2010/BMD-2402 to RG).MDCOC receives grant support from the Ministerio de Educación, Cultura y Deporte, grant number FPU16/03895 and MEG is supported by the “Miguel Servet Program” (CP16/00046) from Instituto de Salud Carlos III (Spanish of MinistrHealth)Project
Gobierno de España. PI10/0703; Gobierno de España. PI13/00556; Gobierno de España. PI16/00789; Gobierno de España. PI15/00484; Gobierno de España. ER16P3AC717; Comunidad de Madrid. S2010/BMD-2402/MITOLAB; Gobierno de España. FPU16/03895; Gobierno de España. CP16/00046Editor's Version
https://doi.org/10.1016/j.scr.2018.02.009Subjects
IISHDOi002-A; Dermal fibroblasts; African mitochondrial haplogroup; Factors Oct3/4, Sox2, Klf4 and cMyc; Sendai virus; MedicinaRights
© 2018 The AuthorsEsta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Abstract
We have generated a human iPSC line, IISHDOi002-A, from commercial primary normal human dermal fibroblasts belonging to an African mitochondrial haplogroup (L3), and with a 46, XY/47, XYY mosaicism. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4 and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus
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Google Scholar:Ortuño-Costela, María del Carmen
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Moreno-Izquierdo, Ana
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Garesse Alarcón, Rafael
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Gallardo, M. Esther
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