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Generation of a human iPSC line, IISHDOi002-A, with a 46, XY/47, XYY mosaicism and belonging to an African mitochondrial haplogroup

dc.contributor.authorOrtuño-Costela, María del Carmen
dc.contributor.authorMoreno-Izquierdo, Ana
dc.contributor.authorGaresse Alarcón, Rafael 
dc.contributor.authorGallardo, M. Esther
dc.contributor.otherUAM. Departamento de Bioquímicaes_ES
dc.contributor.otherCentro de Biología Molecular Severo Ochoa (CBM)es_ES
dc.date.accessioned2018-05-28T11:44:00Z
dc.date.available2018-05-28T11:44:00Z
dc.date.issued2018-04-01
dc.identifier.citationStem Cell Research 28 (2018): 131-135en_US
dc.identifier.issn1873-5061 (print)es_ES
dc.identifier.issn1876-7753 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/682534
dc.description.abstractWe have generated a human iPSC line, IISHDOi002-A, from commercial primary normal human dermal fibroblasts belonging to an African mitochondrial haplogroup (L3), and with a 46, XY/47, XYY mosaicism. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4 and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virusen_US
dc.description.sponsorshipThis work was supported by grants from: 1) the “Fondo de Investigación Sanitaria, Instituto de Salud Carlos III”: PI10/0703, PI13/00556 and PI16/00789 to RG and PI15/00484 to MEG cofunded by FEDER, 2) from the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER): grants 13-717/132.05 and ER16P3AC717 to RG and 3) “Comunidad Autónoma de Madrid” (grant number S2010/BMD-2402 to RG).MDCOC receives grant support from the Ministerio de Educación, Cultura y Deporte, grant number FPU16/03895 and MEG is supported by the “Miguel Servet Program” (CP16/00046) from Instituto de Salud Carlos III (Spanish of MinistrHealth)en_US
dc.format.extent5 pag.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoengen
dc.publisherELsevieren_US
dc.relation.ispartofStem Cell Researchen_US
dc.rights© 2018 The Authorsen_US
dc.subject.otherIISHDOi002-Aen_US
dc.subject.otherDermal fibroblastsen_US
dc.subject.otherAfrican mitochondrial haplogroupen_US
dc.subject.otherFactors Oct3/4, Sox2, Klf4 and cMycen_US
dc.subject.otherSendai virusen_US
dc.titleGeneration of a human iPSC line, IISHDOi002-A, with a 46, XY/47, XYY mosaicism and belonging to an African mitochondrial haplogroupen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.scr.2018.02.009es_ES
dc.identifier.doi10.1016/j.scr.2018.02.009es_ES
dc.identifier.publicationfirstpage131es_ES
dc.identifier.publicationissue28es_ES
dc.identifier.publicationlastpage135es_ES
dc.identifier.publicationvolumeStem Cell Researchen_US
dc.relation.projectIDGobierno de España. PI10/0703es_ES
dc.relation.projectIDGobierno de España. PI13/00556es_ES
dc.relation.projectIDGobierno de España. PI16/00789es_ES
dc.relation.projectIDGobierno de España. PI15/00484es_ES
dc.relation.projectIDGobierno de España. ER16P3AC717es_ES
dc.relation.projectIDComunidad de Madrid. S2010/BMD-2402/MITOLABes_ES
dc.relation.projectIDGobierno de España. FPU16/03895es_ES
dc.relation.projectIDGobierno de España. CP16/00046es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimiento – NoComercial – SinObraDerivadaes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMGaresse Alarcón, Rafael (259828)
dc.facultadUAMFacultad de Medicina


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