Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

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dc.contributor.author Torralba, Daniel
dc.contributor.author Baixauli, Francesc
dc.contributor.author Villarroya Beltri, Carolina
dc.contributor.author Fernández-Delgado, Irene
dc.contributor.author Latorre-Pellicer, Ana
dc.contributor.author Acín-Pérez, Rebeca
dc.contributor.author Martín-Cófreces, Noa
dc.contributor.author Jaso-Tamame, Ángel Luis
dc.contributor.author Iborra, Salvador
dc.contributor.author Jorge, Inmaculada
dc.contributor.author González-Aseguinolaza, Gloria
dc.contributor.author Garaude, Johan
dc.contributor.author Vicente-Manzanares, Miguel
dc.contributor.author Enríquez, José Antonio
dc.contributor.author Mittelbrunn, María
dc.contributor.author Sánchez-Madrid, Francisco
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP) es_ES
dc.date.accessioned 2018-09-20T11:14:07Z
dc.date.available 2018-09-20T11:14:07Z
dc.date.issued 2018-07-09
dc.identifier.citation Nature Communications 9.1 (2018): 2658 en_US
dc.identifier.issn 2041-1723 es_ES
dc.identifier.uri http://hdl.handle.net/10486/685137
dc.description.abstract Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats en_US
dc.description.sponsorship This study was supported by grants SAF2017/82886-R from the Spanish Ministry of Economy and Competitiveness, CAM S2017/BMD-3671 from the Comunidad de Madrid, CIBER Cardiovascular (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER), ERC-2011-AdG 294340-GENTRIS and COST-Action BM1202 to F.S.-M.; grant SAF2015-65633-R from the Spanish Ministry of Economy and Competitiveness to J.A.E. M.M. is supported by MS14/00219 from Instituto de Salud Carlos III. Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). en_US
dc.format.extent 17 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Nature Research (part of Springer Nature) en_US
dc.relation.ispartof Nature Communications en_US
dc.rights © 2018 The Author(s) e
dc.subject.other T cell en_US
dc.subject.other Dendritic cells (DC en_US
dc.subject.other Extracellular vesicles en_US
dc.subject.other DNA en_US
dc.subject.other Contacts en_US
dc.title Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41467-018-05077-9 es_ES
dc.identifier.doi 10.1038/s41467-018-05077-9 es_ES
dc.identifier.publicationfirstpage 2658-1 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 2658-17 es_ES
dc.identifier.publicationvolume 9 es_ES
dc.relation.projectID Gobierno de España. SAF2017/82886-R es_ES
dc.relation.projectID Comunidad de Madrid. S2017/BMD-3671/INFLAMUNE es_ES
dc.relation.projectID Gobierno de España. ERC-2011-AdG 294340-GENTRIS es_ES
dc.relation.projectID COST-Action BM1202 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess es_ES
dc.authorUAM Mittelbrum Herrero, María (279535)
dc.authorUAM Villarroya Beltrí, Carolina (264703)
dc.authorUAM Sánchez Madrid, Francisco (259404)


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