Physical activity, sitting time, and mortality from inflammatory diseases in older adults

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dc.contributor.author Cabanas-Sánchez, V.
dc.contributor.author Guallar-Castillón, Pilar
dc.contributor.author Higueras-Fresnillo, Sara
dc.contributor.author García-Esquinas, Esther
dc.contributor.author Rodríguez-Artalejo, Fernando
dc.contributor.author Martínez-Gómez, David
dc.contributor.other UAM. Departamento de Educación Física, Deporte y Motricidad Humana es_ES
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) es_ES
dc.date.accessioned 2018-09-24T16:05:43Z
dc.date.available 2018-09-24T16:05:43Z
dc.date.issued 2018-07-12
dc.identifier.citation Frontiers in Physiology 9 July (2018): 898 en_US
dc.identifier.issn 1664-042X es_ES
dc.identifier.uri http://hdl.handle.net/10486/685171
dc.description.abstract Objective: The aim of this study was to examine the independent and combined associations of physical activity (PA) and sitting time (ST) with long-term mortality attributed to inflammatory causes other than cardiovascular disease (CVD) and cancer in a national cohort of older adults in Spain. Design: Prospective study. Setting and Participants: A cohort of 3,677 individuals (1,626 men) aged =60 years was followed-up during 14.3 years. Measures: At baseline, individuals reported PA and ST. The study outcome was death from inflammatory diseases when CVD or cancer mortality was excluded. This outcome was classified into infectious and non-infectious conditions. Analyses were performed with Cox regression and adjusted for PA, ST, and other main confounders (age, sex, educational level, smoking, alcohol consumption, body mass index, and chronic conditions). Results: During follow-up, 286 deaths from inflammatory diseases (77 from infectious diseases) were identified. Compared to individuals who defined themselves as inactive/less active, mortality from inflammatory diseases was lower in those who were moderately active (hazard ratio [HR] = 0.67, 95% confidence interval [CI] = 0.50-0.90) or very active (HR = 0.48, 95%CI = 0.33-0.68), independently of ST. Also, being seated ≥7 h/d vs. < 7 h/d was linked to higher mortality (HR = 1.38, 95%CI = 1.02-1.87). The largest risk of mortality was observed in inactive/less active individuals with ST≥7 h/d (HR = 2.29, 95%CI = 1.59-3.29) compared to those with moderate/very PA and ST < 7 h/d. Low PA and high ST were consistently associated with a higher risk of mortality from non-infectious inflammatory causes. Associations of PA and ST with mortality from infectious inflammatory causes showed a similar trend, but most of them did not reach statistical significance. Conclusions: Low PA and high ST were independently associated with higher mortality from inflammatory diseases other than CVD or cancer in older adults. Interventions addressing simultaneously both behaviors could have greater benefits than those focusing on only one of them en_US
dc.description.sponsorship This work was supported by FIS grant 16/609 (Instituto de Salud Carlos III, State Secretary of R+D+I and FEDER/FSE), MINECO R+D+I grant (DEP2013-47786-R), MECD mobility grant (JC2015-00080), the FRAILOMIC Initiative (European Union FP7-HEALTH-2012-Proposal No. 305483-2), and the ATHLOS project (European project H2020- Project ID: 635316) en_US
dc.format.extent 8 pag. es_ES
dc.format.mimetype application/pdf en_US
dc.language.iso eng en
dc.publisher Frontiers Media en_US
dc.relation.ispartof Frontiers in Physiology en_US
dc.rights © 2018 Cabanas-Sánchez, Guallar-Castillón, Higueras-Fresnillo, García-Esquinas, Rodríguez-Artalejo and Martinez-Gomez. es_ES
dc.subject.other Infectious diseases en_US
dc.subject.other Inflammation diseases en_US
dc.subject.other Mortality en_US
dc.subject.other Physical activity en_US
dc.subject.other Sitting time en_US
dc.title Physical activity, sitting time, and mortality from inflammatory diseases in older adults en_US
dc.type article en
dc.subject.eciencia Deportes es_ES
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.3389/fphys.2018.00898 es_ES
dc.identifier.doi 10.3389/fphys.2018.00898 es_ES
dc.identifier.publicationfirstpage 898-1 es_ES
dc.identifier.publicationissue July es_ES
dc.identifier.publicationlastpage 898-8 es_ES
dc.identifier.publicationvolume 9 es_ES
dc.relation.projectID Gobierno de España. DEP2013-47786-R es_ES
dc.relation.projectID Gobierno de España. JC2015-00080 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/305483-2 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/635316/EU//ATHLOS es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Cabanas Sánchez, Verónica (264614)


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