Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain: The MCC-Spain study

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dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Dierssen-Sotos, Trinidad
dc.contributor.author De Pedro, María
dc.contributor.author Pérez-Gómez, Beatriz
dc.contributor.author Castaño-Vinyals, Gemma
dc.contributor.author Fernández-Villa, Tania
dc.contributor.author Palazuelos, Camilo
dc.contributor.author Amiano, Pilar
dc.contributor.author Etxeberria, Jaione
dc.contributor.author Benavente, Yolanda
dc.contributor.author Fernández-Tardón, Guillermo
dc.contributor.author Salcedo-Bellido, Inmaculada
dc.contributor.author Capelo, Rocío
dc.contributor.author Peiró, Rosana
dc.contributor.author Marcos-Gragera, Rafael
dc.contributor.author Huerta, José M.
dc.contributor.author Tardón, Adonina
dc.contributor.author Barricarte, Aurelio
dc.contributor.author Altzibar, Jone Miren
dc.contributor.author Alonso-Molero, Jessica
dc.contributor.author Dávila-Batista, Verónica
dc.contributor.author Aragonés, Nuria
dc.contributor.author Pollán, Marina
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Llorca, Javier
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.date.accessioned 2018-12-11T12:47:24Z
dc.date.available 2018-12-11T12:47:24Z
dc.date.issued 2018-09-21
dc.identifier.citation BMC Public Health 18.1 (2018): 1134 en_US
dc.identifier.issn 1471-2458 es_ES
dc.identifier.uri http://hdl.handle.net/10486/685834
dc.description.abstract Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. Methods: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression. Results: Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4-49.1) in younger than 45 to 21.1% (18.3-24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (≥75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4-31.2) in women with acute coronary syndrome, 13.3 (6.2-28.3) in women with strokes and 11.1 (7.8-15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions. Conclusions: Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage en_US
dc.description.sponsorship This work was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/ 00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10–2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOODCT- 2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo en_US
dc.format.extent 13 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Springer Nature en_US
dc.relation.ispartof BMC Public Health en_US
dc.rights © 2018 The Author(s) en_US
dc.subject.other Aspirin en_US
dc.subject.other Cardiovascular risk en_US
dc.subject.other Gastrointestinal bleeding en_US
dc.subject.other Non-steroidal anti-inflammatory drugs en_US
dc.subject.other Propionates en_US
dc.title Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain: The MCC-Spain study en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1186/s12889-018-6019-z es_ES
dc.identifier.doi 10.1186/s12889-018-6019-z es_ES
dc.identifier.publicationfirstpage 1134-1 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 1134-13 es_ES
dc.relation.projectID Gobierno de España. PI08/1770 es_ES
dc.relation.projectID Gobierno de España. PI08/0533 es_ES
dc.relation.projectID Gobierno de España. RD12/0036/0036 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/036224 en_US
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Pollán Santamaría, Marina Anunciación (262007)

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