dc.contributor.author | Martínez, Ángel Manu | |
dc.contributor.author | Rodríguez Garrido, Nuria | |
dc.contributor.author | Gómez Arrayas, Ramón Jesús | |
dc.contributor.author | Carretero Gonzálvez, Juan Carlos | |
dc.contributor.other | UAM. Departamento de Química Orgánica | es_ES |
dc.date.accessioned | 2018-12-14T12:23:03Z | |
dc.date.available | 2018-12-14T12:23:03Z | |
dc.date.issued | 2017-01-01 | |
dc.identifier.citation | Chemistry – A European Journal 23.48 (2017): 11669 - 11676 | en_US |
dc.identifier.issn | 0947-6539 (print) | en_US |
dc.identifier.issn | 1521-3765 (online) | en_US |
dc.identifier.uri | http://hdl.handle.net/10486/685957 | |
dc.description.abstract | A practical picolinamide-directed C−H functionalization/alkyne annulation of benzylamine derivatives enabling access to the previously elusive 1,4-dihydroisoquinoline skeleton was developed using molecular O2as the sole oxidant and Co(OAc)2as precatalyst. The method is compatible with both internal and terminal alkynes and shows high versatility and functional-group tolerance. Furthermore, full preservation of enantiopurity is observed when using non-racemic α-substituted benzylamine derivatives. Kinetic analysis of the reagents and catalyst, labeling experiments, and the isolation and identification of catalytically competent Co-complexes revealed important insights about the mechanism | en_US |
dc.description.sponsorship | We thank the Spanish Ministerio de Economía, Industriay Competitividad (MINECO,Grants CTQ2012-35790andCTQ2015-66954-P,MINECO/FEDER,UE) for financial support.N.R. thanks the MICINN for a Ramón y Cajal contract and the European Commission for a Marie Curie Career Integration Grant (CIG:CHAAS-304085) | en_US |
dc.format.extent | 10 pag. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Chemistry - A European Journal | en_US |
dc.rights | © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | es_ES |
dc.subject.other | alkyne | en_US |
dc.subject.other | annulation | en_US |
dc.subject.other | cobalt | en_US |
dc.subject.other | dihydroisoquinoline | en_US |
dc.subject.other | picolinamide | en_US |
dc.title | Cobalt-Catalyzed ortho-C−H functionalization/alkyne annulation of benzylamine derivatives: Access to dihydroisoquinolines | en_US |
dc.type | article | en_US |
dc.subject.eciencia | Química | es_ES |
dc.date.embargoend | 2018-06-21 | |
dc.relation.publisherversion | http://doi.org/10.1002/chem.201702283 | es_ES |
dc.identifier.doi | 10.1002/chem.201702283 | es_ES |
dc.identifier.publicationfirstpage | 11669 | es_ES |
dc.identifier.publicationissue | 48 | es_ES |
dc.identifier.publicationlastpage | 11676 | es_ES |
dc.identifier.publicationvolume | 23 | es_ES |
dc.relation.projectID | Gobierno de España. CTQ2012-35790 | es_ES |
dc.relation.projectID | Gobierno de España. CTQ2015-66954-P | es_ES |
dc.type.version | info:eu-repo/semantics/acceptedVersion | en |
dc.rights.accessRights | openAccess | en_US |
dc.authorUAM | Carretero Gonzálvez, Juan Carlos (260121) | |
dc.facultadUAM | Facultad de Ciencias | |
dc.institutoUAM | Instituto de Investigación Avanzada en Ciencias Químicas (IAdChem) | |