Show simple item record

dc.contributor.authorMayoral, María José
dc.contributor.authorSerrano-Molina, David
dc.contributor.authorCamacho-García, Jorge
dc.contributor.authorMagdalena-Estirado, Eva
dc.contributor.authorBlanco-Lomas, Marina
dc.contributor.authorFadaei, Elham
dc.contributor.authorGonzález Rodríguez, David 
dc.contributor.otherUAM. Departamento de Química Orgánicaes_ES
dc.contributor.otherUAM. Instituto de Investigación Avanzada en Ciencias Químicas (IAdChem)es_ES
dc.date.accessioned2018-12-19T18:16:04Z
dc.date.available2018-12-19T18:16:04Z
dc.date.issued2018-08-20
dc.identifier.citationChemical Science 9.40 (2018): 7809-7821en_US
dc.identifier.issn2041-6520 (print)es_ES
dc.identifier.issn2041-6539 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/686105
dc.description.abstractAs molecular self-assembled systems increase in complexity, due to a large number of participating entities and/or the establishment of multiple competing equilibria, their full understanding becomes likewise more complicated, and the use of diverse analytical techniques that can afford complementary information is required. We demonstrate in this work that resonance excitation energy transfer phenomena, measured by fluorescence spectroscopy in combination with other optical spectroscopies, can be a valuable tool to obtain supplementary thermodynamic data about complex supramolecular landscapes that other methods fail to provide. In particular, noncovalent macrocyclization processes of lipophilic dinucleosides are studied here by setting up a competition between intra- and intermolecular association processes of Watson-Crick H-bonding pairs. Multiwavelength analysis of the monomer emission changes allowed us to determine cyclotetramerization constants and to quantify chelate cooperativity, which was confirmed to be substantially larger for the G-C than for the A-U pair. Furthermore, when bithiophene-BODIPY donor-acceptor energy transfer probes are employed in these competition experiments, fluorescence and circular dichroism spectroscopy measurements in different regions of the visible spectrum additionally reveal intermolecular interactions occurring simultaneously at both sides of the macrocyclization reaction: the cyclic product, acting as a host for the competitor, and the monomer reactant, ultimately leading to macrocycle denaturationen_US
dc.description.sponsorshipFunding from the European Research Council (ERC-Starting Grant 279548 PROGRAM-NANO) and MINECO (CTQ2014-57729 P and CTQ2017-84727 P) is gratefully acknowledged. E. F. would like to thank Sharif University of Technology of Iran for financial support. D. S.-M. would like to acknowledge Comunidad de Madrid for financial support through contract PEJ16/IND/AI-0849en_US
dc.format.extent13 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofChemical Scienceen_US
dc.rights© The Royal Society of Chemistryen_US
dc.subject.otherMolecular self-assembled systemen_US
dc.subject.otherAnalytical techniquesen_US
dc.subject.otherExcitation energyen_US
dc.subject.otherThermodynamicen_US
dc.subject.otherWatson–Crick H-bonding pairsen_US
dc.subject.otherMacrocyclization reactionen_US
dc.titleUnderstanding complex supramolecular landscapes: Non-covalent macrocyclization equilibria examined by fluorescence resonance energy transferen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.relation.publisherversionhttps://doi.org/10.1039/c8sc03229ges_ES
dc.identifier.doi10.1039/c8sc03229ges_ES
dc.identifier.publicationfirstpage7809es_ES
dc.identifier.publicationissue40es_ES
dc.identifier.publicationlastpage7821es_ES
dc.identifier.publicationvolume9es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/279548es_ES
dc.relation.projectIDGobierno de España. CTQ2014- 57729 Pes_ES
dc.relation.projectIDGobierno de España. CTQ2017-84727 Pes_ES
dc.relation.projectIDComunidad de Madrid. PEJ16/IND/AI-0849es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.contributor.groupNanostructured Molecular Systems and Materials Groupen_US
dc.rights.ccReconocimiento – NoComerciales_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMMayoral Muñoz, María José (264926)
dc.authorUAMBlanco Lomas, Marina (271721)
dc.authorUAMGonzález Rodríguez, David (260340)
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMInstituto de Investigación Avanzada en Ciencias Químicas (IAdChem)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record