dc.contributor.author | Sánchez Niño, María Dolores | |
dc.contributor.author | Ortiz Arduán, Alberto | |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.contributor.other | Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM) | es_ES |
dc.date.accessioned | 2018-12-20T12:37:17Z | |
dc.date.available | 2018-12-20T12:37:17Z | |
dc.date.issued | 2018-10-01 | |
dc.identifier.citation | Clinical Kidney Journal 11.5 (2018): 688–690 | en_US |
dc.identifier.issn | 2048-8505 (print) | es_ES |
dc.identifier.issn | 2048-8513 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/686114 | |
dc.description.abstract | Drug-induced hypertension offers the opportunity to further understand pathways involved in the regulation of blood pressure. Posaconazole is an antifungal agent known to induce hypertension and hypokalaemia. In recent months, a flurry of reports has unravelled the metabolic processes involved. In this issue of CKJ, Barton K, Davis TK, Marshall B et al. Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme. Clin Kidney J 2018; 11: 691-693 present convincing evidence of 11β-hydroxylase inhibition resulting in a biochemical syndrome resembling genetic congenital adrenal hyperplasia and characterized by high 11-deoxycorticosterone and 11-deoxycortisol levels as well as androgen levels. This adds to prior evidence supporting inhibition of 11β-hydroxysteroid dehydrogenase 2, the enzyme that inactivates cortisol in aldosterone-sensitive tissues such as the kidneys, yielding a syndrome resembling genetic apparent mineralocorticoid excess or licorice toxicity, characterized by a high cortisol/cortisone ratio | en_US |
dc.description.sponsorship | The authors were supported by FIS PI16/02057, PI18/01366, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet MS14/00133 to M.D.S.-N. | en_US |
dc.format.extent | 3 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Oxford University Press on behalf of ERA-EDTA | en_US |
dc.relation.ispartof | Clinical Kidney Journal | en_US |
dc.rights | © The Author(s) 2018 | en_US |
dc.subject.other | 11-deoxycortisol | en_US |
dc.subject.other | 11b-hydroxylase | en_US |
dc.subject.other | 11b-hydroxysteroid dehydrogenase 2 | en_US |
dc.subject.other | Antifungal | en_US |
dc.subject.other | Drug-induced hypertension | en_US |
dc.title | Unravelling drug-induced hypertension: Molecular mechanisms of aldosterone-independent mineralocorticoid receptor activation by posaconazole | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1093/ckj/sfy087 | es_ES |
dc.identifier.doi | 10.1093/ckj/sfy087 | es_ES |
dc.identifier.publicationfirstpage | 686 | es_ES |
dc.identifier.publicationissue | 5 | es_ES |
dc.identifier.publicationlastpage | 690 | es_ES |
dc.identifier.publicationvolume | 11 | es_ES |
dc.relation.projectID | Gobierno de España. FIS PI16/02057 | es_ES |
dc.relation.projectID | Gobierno de España. PI18/01366 | es_ES |
dc.relation.projectID | Gobierno de España. RD016/0009 | es_ES |
dc.relation.projectID | Comunidad de Madrid. B2017/BMD-3686/CIFRA2 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento – NoComercial | es_ES |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM) | |