Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer's disease

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dc.contributor.author Van der Wee, Nic J.A.
dc.contributor.author Bilderbeck, Amy C.
dc.contributor.author Cabello, María
dc.contributor.author Ayuso Mateos, José Luis
dc.contributor.author Saris, Ilya M.J.
dc.contributor.author Giltay, Erik J.
dc.contributor.author Penninx, Brenda W.J.H.
dc.contributor.author Arango, Celso
dc.contributor.author Post, Anke
dc.contributor.author Porcelli, Stefano
dc.date.accessioned 2018-12-20T14:49:52Z
dc.date.available 2018-12-20T14:49:52Z
dc.date.issued 2018-01-01
dc.identifier.citation Neuroscience and Biobehavioral Reviews, Junio (2018): 1-9 en_US
dc.identifier.issn 0149-7634 es_ES
dc.identifier.uri http://hdl.handle.net/10486/686116
dc.description.abstract Social withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers (PRISM) project focusses on the shared and unique neurobiological basis of social withdrawal in schizophrenia, Alzheimer and depression. In this paper, we discuss the working definition of social withdrawal for this study and the selection of objective and subjective rating scales to assess social withdrawal chosen or adapted for this project. We also discuss the MRI and EEG paradigms selected to study the systems and neural circuitry thought to underlie social functioning and more particularly to be involved in social withdrawal in humans, such as the social perception and the social affiliation networks. A number of behavioral paradigms were selected to assess complementary aspects of social cognition. Also, a digital phenotyping method (a smartphone application) was chosen to obtain real-life data. en_US
dc.description.sponsorship This work was supported by the European Union Horizon 2020 Innovative Medicines Initiative 2 Joint Undertaking grant 115916 for the project ‘Psychiatric ratings using intermediate stratified markers’ en_US
dc.format.extent 9 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Elsevier Ltd. es_ES
dc.relation.ispartof Neuroscience and Biobehavioral Reviews es_ES
dc.rights © 2018 The Authors en_US
dc.subject.other Digital phenotyping en_US
dc.subject.other EEG en_US
dc.subject.other MRI en_US
dc.subject.other Neurobiological and behavioral paradigms in schizophrenia, Alzheimer and depression en_US
dc.subject.other Passive remote monitoring en_US
dc.subject.other PRISM en_US
dc.subject.other Social withdrawal en_US
dc.subject.other Subjective and objective assessments en_US
dc.title Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer's disease en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.neubiorev.2018.06.020 es_ES
dc.identifier.doi 10.1016/j.neubiorev.2018.06.020 es_ES
dc.identifier.publicationfirstpage 1 es_ES
dc.identifier.publicationlastpage 9 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/115916/EU//PRISM es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM Ayuso Mateos, José Luis (260480)
dc.authorUAM Cabello Salmeron, María (314110)


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