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Thermodynamic and Kinetic Stabilities of G-Quadruplexes in Apolar Solvents

dc.contributor.authorFadaei, Elham
dc.contributor.authorMartín-Arroyo, Miguel
dc.contributor.authorTafazzoli, Mohsen
dc.contributor.authorGonzález Rodríguez, David 
dc.contributor.otherUAM. Departamento de Química Orgánicaes_ES
dc.contributor.otherUAM. Instituto de Investigación Avanzada en Ciencias Químicas (IAdChem)es_ES
dc.date.accessioned2019-05-07T08:48:11Z
dc.date.available2019-05-07T08:48:11Z
dc.date.issued2017-01-19
dc.identifier.citationOrganic Letters 19.3 (2017): 460-463en_US
dc.identifier.issn1523-7060 (print)en_US
dc.identifier.issn1523-7052 (online)en_US
dc.identifier.urihttp://hdl.handle.net/10486/687406
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03606en_US
dc.description.abstractIn contrast to more polar media, G-quadruplex assembly reveals remarkably high thermodynamic and kinetic stability in toluene solutions. Depending on the substituents installed at the lipophilic guanosine, either a dodecamer or an octamer complex is formed in the presence of K+ or Na+ salts that resist conditions of high dilution and elevated temperatures without exhibiting significant dissociation. Moreover, kinetic exchange between complexed and uncomplexed G is slow enough in NMR to monitor G-quadruplex formation along a day time scaleen_US
dc.description.sponsorshipThe EU (ERC-Starting Grant 279548) and MINECO (CTQ2014-57729-P) is gratefully acknowledged. E.F. thanks Sharif University of Technology of Iran for financial support. M.M.-A. acknowledges a FPI grant from MINECOen_US
dc.format.extent5 pag.en_US
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofOrganic Lettersen_US
dc.rights© 2017 American Chemical Societyen_US
dc.subject.otherG-Quadruplexesen_US
dc.subject.otherSelf assemblyen_US
dc.subject.otherCircular dichroismen_US
dc.titleThermodynamic and Kinetic Stabilities of G-Quadruplexes in Apolar Solventsen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.date.embargoend2018-01-19
dc.relation.publisherversionhttp://dx.doi.org/10.1021/acs.orglett.6b03606es_ES
dc.identifier.doi10.1021/acs.orglett.6b03606es_ES
dc.identifier.publicationfirstpage460es_ES
dc.identifier.publicationissue3es_ES
dc.identifier.publicationlastpage463es_ES
dc.identifier.publicationvolume19es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/279548en_US
dc.relation.projectIDGobierno de España. CTQ2014-57729-Pes_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMInstituto de Investigación Avanzada en Ciencias Químicas (IAdChem)


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