dc.contributor.author | Gómez-Acebo, Inés | |
dc.contributor.author | Dierssen-Sotos, Trinidad | |
dc.contributor.author | Palazuelos, Camilo | |
dc.contributor.author | Fernández-Navarro, Pablo | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Alonso-Molero, Jéssica | |
dc.contributor.author | Urtiaga, Carmen | |
dc.contributor.author | Fernández-Villa, Tania | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | Rivas-del-Fresno, Manuel | |
dc.contributor.author | Molina-Barceló, Ana | |
dc.contributor.author | Jiménez-Moleón, José Juan | |
dc.contributor.author | García-Martínez, Lidia | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Rodríguez-Cundín, Paz | |
dc.contributor.author | Moreno, Víctor | |
dc.contributor.author | Pérez-Gómez, Beatriz | |
dc.contributor.author | Aragonés, Nuria | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pollán Santamaría, Marina Anunciación | |
dc.contributor.author | Llorca, Javier | |
dc.date.accessioned | 2019-06-04T16:46:30Z | |
dc.date.available | 2019-06-04T16:46:30Z | |
dc.date.issued | 2018-08-14 | |
dc.identifier.citation | PLoS ONE 13.8 (2018): e0201750 | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/687678 | |
dc.description.abstract | Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. Methods We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype—cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. Results The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. Conclusions Phototype is not associated with breast or prostate cancer. | en_US |
dc.description.sponsorship | This work was partially funded by the ªAccion Transversal del Cáncer", approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER
[PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia,
PI09/02078-Huelva, PI09/01662-Granada, PI11/
01403, PI11/01889-FEDER, PI11/00226, PI11/
01810, PI11/02213, PI12/00488, PI12/00265,
PI12/01270, PI12/00715, PI12/00150, PI14/01219,
PI14/0613, PI15/00069, PI15/00914, PI15/01032];
The Fundación Marqués de Valdecilla [API 10/09];
The ICGC International Cancer Genome
Consortium CLL (The ICGC CLL-Genome Project is
funded by Spanish Ministerio de Economía y
Competitividad (MINECO) through the Instituto de
Salud Carlos III (ISCIII) and Red Temática de
Investigación del Cáncer (RTICC) del ISCIII (RD12/
0036/0036)); The Junta de Castilla y León
[LE22A10-2]; The Consejería de Salud of the Junta
de Andalucía [2009-S0143]; The Conselleria de
Sanitat of the Generalitat Valenciana [AP_061/10];
The Recercaixa [2010ACUP 00310]; The Regional
Government of the Basque Country; The Consejería
de Sanidad de la Región de Murcia; The European
Commission [grants FOOD-CT-2006-036224-
HIWATE]; The Spanish Association Against Cancer
(AECC) Scientific Foundation; The Catalan
Government DURSI [grant 2014SGR647]; The
Fundación Caja de Ahorros de Asturias; and the
University of Oviedo. | en_US |
dc.format.extent | 15 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLos ONE | en_US |
dc.rights | © 2018 Gómez-Acebo et al. | es_ES |
dc.subject.other | Prostate cancer | en_US |
dc.subject.other | Phototype and breast | en_US |
dc.subject.other | Genetic pigmentation | en_US |
dc.subject.other | Mendelian randomization analysis | en_US |
dc.title | Pigmentation phototype and prostate and breast cancer in a select Spanish population: A Mendelian randomization analysis in the MCC-Spain study | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https:// doi.org/10.1371/journal.pone.0201750 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0201750 | es_ES |
dc.identifier.publicationfirstpage | e0201750-1 | es_ES |
dc.identifier.publicationissue | 8 | es_ES |
dc.identifier.publicationlastpage | e0201750-15 | es_ES |
dc.identifier.publicationvolume | 13 | es_ES |
dc.relation.projectID | Gobierno de España. PI08/1770 | es_ES |
dc.relation.projectID | Gobierno de España. PI08/0533 | es_ES |
dc.relation.projectID | Gobierno de España. PI08/1359 | es_ES |
dc.relation.projectID | Gobierno de España. PI11/ 01403 | es_ES |
dc.relation.projectID | Gobierno de España. PI11/01889-FEDER | es_ES |
dc.relation.projectID | Gobierno de España. PI11/00226 | es_ES |
dc.relation.projectID | Gobierno de España. PI11/ 01810, | es_ES |
dc.relation.projectID | Gobierno de España. PI11/02213 | es_ES |
dc.relation.projectID | Gobierno de España. PI12/00488 | es_ES |
dc.relation.projectID | Gobierno de España. PI12/00265 | es_ES |
dc.relation.projectID | Gobierno de España. PI12/01270 | es_ES |
dc.relation.projectID | Gobierno de España. PI12/00715 | es_ES |
dc.relation.projectID | Gobierno de España. PI12/00150 | es_ES |
dc.relation.projectID | Gobierno de España. PI14/01219 | es_ES |
dc.relation.projectID | Gobierno de España. PI14/0613 | es_ES |
dc.relation.projectID | Gobierno de España. PI15/00069 | es_ES |
dc.relation.projectID | Gobierno de España. PI15/00914 | es_ES |
dc.relation.projectID | Gobierno de España. PI15/01032 | es_ES |
dc.relation.projectID | Gobierno de España. RD12/0036/0036 | es_ES |
dc.relation.projectID | info:eurepo/grantAgreement/EC/FP7/036224 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | es_ES |
dc.authorUAM | Pollán Santamaría, Marina Anunciación (262007) | |
dc.facultadUAM | Facultad de Medicina | |