Frontotemporal dementia-associated N279K tau mutation localizes at the nuclear compartment

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dc.contributor.author Ritter, Maxi L.
dc.contributor.author Avila, Jesús
dc.contributor.author García-Escudero, Vega
dc.contributor.author Hernández, Félix
dc.contributor.author Pérez, Mar
dc.contributor.other UAM. Departamento de Anatomía, Histología y Neurociencia es_ES
dc.contributor.other Centro de Biología Molecular Severo Ochoa (CBMSO) es_ES
dc.date.accessioned 2019-06-17T17:02:25Z
dc.date.available 2019-06-17T17:02:25Z
dc.date.issued 2018-07-12
dc.identifier.citation Frontiers in Cellular Neuroscience 12 (2018): 202 en_US
dc.identifier.issn 1662-5102 es_ES
dc.identifier.uri http://hdl.handle.net/10486/687877
dc.description.abstract Tau is a microtubule-associated protein that plays an important role in Alzheimer’s disease and related tauopathies. Approximately one-half of all cases of Frontotemporal dementia with parkinsonism-17 (FTDP-17) are caused by mutations in the MAPT gene. The N279K mutation is one of the three mutations more prevalent in FTDP-17 cases. Several studies have demonstrated that N279K Tau mutation alters alternative splicing inducing the presence of exon 10. Tau is mainly found in the cytosol of neuronal cells although it has also been localized within the nucleus. Here we demonstrate by biochemical and immunohistochemistry studies in COS-7 cells, that the proportion of mutant N279K Tau increases compared with wild-type at the cell nucleus although cell viability is not affected. These data will provide us with a better outline of the nuclear role of tau protein offering new clues related with this tauopathie. en_US
dc.description.sponsorship This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad; SAF-2014-53040-P (JA) and BFU2016-77885- P (FH)), the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII; JA). en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Frontiers Media en_US
dc.relation.ispartof Frontiers in Cellular Neuroscience en_US
dc.rights © 2018 Ritter, Avila, García-Escudero, Hernández and Pérez es_ES
dc.subject.other Alzheimer en_US
dc.subject.other FTDP-17 en_US
dc.subject.other Nucleus en_US
dc.subject.other Tau en_US
dc.subject.other Transport en_US
dc.title Frontotemporal dementia-associated N279K tau mutation localizes at the nuclear compartment en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.3389/fncel.2018.00202 es_ES
dc.identifier.doi 10.3389/fncel.2018.00202 es_ES
dc.identifier.publicationfirstpage 202-1 es_ES
dc.identifier.publicationissue 12 es_ES
dc.identifier.publicationlastpage 202-10 es_ES
dc.relation.projectID Gobierno de España. SAF-2014-53040-P es_ES
dc.relation.projectID Gobierno de España. BFU2016-77885- P es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimeinto es_ES
dc.rights.accessRights openAccess en


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