dc.contributor.author | Sayas, C. Laura | |
dc.contributor.author | Medina, Miguel | |
dc.contributor.author | Cuadros, Raquel | |
dc.contributor.author | Ollá, Ivanna | |
dc.contributor.author | García García-Esquinas, Esther | |
dc.contributor.author | Pérez Martínez, María Mar | |
dc.contributor.author | Ferrer, Isidro | |
dc.contributor.author | Hernández Pérez, Félix | |
dc.contributor.author | Avila, Jesús | |
dc.contributor.other | UAM. Departamento de Anatomía, Histología y Neurociencia | es_ES |
dc.date.accessioned | 2019-08-14T14:19:14Z | |
dc.date.available | 2019-08-14T14:19:14Z | |
dc.date.issued | 2019-01-22 | |
dc.identifier.citation | PLoS ONE 14.1 (2019): e0210864 | en_US |
dc.identifier.issn | 1932-6203 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/688387 | |
dc.description.abstract | For unknown reasons, humans appear to be particular susceptible to developing tau pathology leading to neurodegeneration. Transgenic mice are still undoubtedly the most popular and extensively used animal models for studying Alzheimer’s disease and other tauopathies. While these murine models generally overexpress human tau in the mouse brain or specific brain regions, there are differences between endogenous mouse tau and human tau protein. Among them, a main difference between human and mouse tau is the presence of a short motif spanning residues 18 to 28 in the human tau protein that is missing in murine tau, and which could be at least partially responsible for that different susceptibility across species. Here we report novel data using affinity chromatography analysis indicating that the sequence containing human tau residues 18 to 28 acts a binding motif for End Binding proteins and that this interaction could facilitate tau secretion to the extracellular space. | es_ES |
dc.description.sponsorship | This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (SAF-2014-53040-P (Jesús Ávila), SAF2016-78603-R (Miguel Medina) and BFU2016-77885-P (Félix Hernández), the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII) (Jesús Ávila). Institutional grants from the Fundación Ramón Areces and Banco Santander to the CBMSO are also acknowledged | en_US |
dc.format.extent | 13 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | spa | en |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLos ONE | en_US |
dc.rights | © 2019 Sayas et al. | es_ES |
dc.subject.other | Neurodegeneration | en_US |
dc.subject.other | Alzheimer’s disease | en_US |
dc.subject.other | Protein | en_US |
dc.subject.other | Brain | en_US |
dc.subject.other | Chromatography analysis | en_US |
dc.title | Role of tau N-terminal motif in the secretion of human tau by end binding proteins | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0210864 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0210864 | es_ES |
dc.identifier.publicationfirstpage | e0210864-1 | es_ES |
dc.identifier.publicationissue | 1 | es_ES |
dc.identifier.publicationlastpage | e0210864-14 | es_ES |
dc.identifier.publicationvolume | 14 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Pérez Martínez, María Mar (261357) | |
dc.facultadUAM | Facultad de Medicina | |