A review of bioactive factors in human breastmilk: A focus on prematurity
Entity
UAM. Departamento de Fisiología; UAM. Departamento de Química AgrícolaPublisher
MDPI AGDate
2019-06-10Citation
10.3390/nu11061307
Nutrients 11.6 (2019): 1307
ISSN
2072-6643DOI
10.3390/nu11061307Funded by
This work was supported by Ministerio de Economia y Competitividad (grant number FEM2015-63631-R) to SMA and the Ministerio de Ciencia, Innovación y Universidades (Spain) (grant number RTI2018-097504-B-100) to SMA and MAM-C. Both grants were co-financed with FEDER fundsProject
Gobierno de España. FEM2015-63631-R; Gobierno de España. RTI2018-097504-B-100Editor's Version
https://doi.org/10.3390/nu11061307Subjects
Adipokines; Antioxidants; Breastfeeding; Cytokines; Growth factors; Biología y Biomedicina / Biología; Ciencia y Tecnología de AlimentosRights
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.Abstract
Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option for the newborn. Its dynamic composition is influenced by diverse factors such as maternal age, lactation period, and health status. The aim of the present review is to summarize the current knowledge regarding some bioactive factors present in breastmilk, namely antioxidants, growth factors, adipokines, and cytokines, paying specific attention to prematurity. The revised literature reveals that the highest levels of these bioactive factors are found in the colostrum and they decrease along the lactation period; bioactive factors are found in higher levels in preterm as compared to full-term milk, they are lacking in formula milk, and decreased in donated milk. However, there are still some gaps and inconclusive data, and further research in this field is needed. Given the fact that many preterm mothers are unable to complete breastfeeding, new information could be important to develop infant supplements that best match preterm human milk
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Google Scholar:Gila-Diaz, Andrea
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Arribas Rodríguez, Silvia Magdalena
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Algara, Alba
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Martín Cabrejas, M. Ángeles
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Pablo, Ángel Luis López de
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Pipaón, Miguel Sáenz de
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Ramiro-Cortijo, David
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