Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
The role of extracellular vesicles in cutaneous remodeling and hair follicle dynamics
Entity
UAM. Departamento de Biología MolecularPublisher
M D P I AGDate
2019-06-01Citation
10.3390/ijms20112758
International Journal of Molecular Sciences 20.11 (2019): 2758
ISSN
1661-6596DOI
10.3390/ijms20112758Funded by
This research was funded by the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (CP 14/00219), Fondo Europeo de Desarrollo Regional (FEDER), H2020-EU.1.1.—European Research Council (ERC-2016-StG 715322-EndoMitTalk), and Instituto de Salud Carlos III (FIS16/188). E.C. was supported by the Atracción de Talento Investigador grant 2017-T2/BMD-5766 (Comunidad de Madrid and Universidad Autónoma de Madrid). G.S.-H. was funded by an FPI grant (Universidad Autónoma de Madrid). M.M. was supported by the Miguel Servet program (Instituto de Investigación del Hospital 12 de Octubre)Project
info:eu-repo/grantAgreement/EC/H2020/715322/EU//EndoMitTalk; Comunidad de Madrid. 2017-T2/BMD-5766; Gobierno de España. CP 14/00219; Gobierno de España. FIS16/188Editor's Version
https://doi.org/10.3390/ijms20112758Subjects
Apoptotic bodies; Exosomes; Extracellular vesicles; Hair cycle; Hair follicles; Immune cells; Skin; Stem cells; Biología y Biomedicina / BiologíaRights
© 2019 by the authorsAbstract
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are cell-derived membranous structures that were originally catalogued as a way of releasing cellular waste products. Since the discovery of their function in intercellular communication as carriers of proteins, lipids, and DNA and RNA molecules, numerous therapeutic approaches have focused on the use of EVs, in part because of their minimized risk compared to cell-based therapies. The skin is the organ with the largest surface in the body. Besides the importance of its body barrier function, much attention has been paid to the skin in regenerative medicine because of its cosmetic aspect, which is closely related to disorders affecting pigmentation and the presence or absence of hair follicles. The use of exosomes in therapeutic approaches for cutaneous wound healing has been reported and is briefly reviewed here. However, less attention has been paid to emerging interest in the potential capacity of EVs as modulators of hair follicle dynamics. Hair follicles are skin appendices that mainly comprise an epidermal and a mesenchymal component, with the former including a major reservoir of epithelial stem cells but also melanocytes and other cell types. Hair follicles continuously cycle, undergoing consecutive phases of resting, growing, and regression. Many biomolecules carried by EVs have been involved in the control of the hair follicle cycle and stem cell function. Thus, investigating the role of either naturally produced or therapeutically delivered EVs as signaling vehicles potentially involved in skin homeostasis and hair cycling may be an important step in the attempt to design future strategies towards the efficient treatment of several skin disorders
Files in this item
Google Scholar:Carrasco, Elisa
-
Soto-Heredero, Gonzalo
-
Mittelbrum Herrero, María
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
Torralba, Daniel; Baixauli, Francesc; Villarroya Beltri, Carolina; Fernández-Delgado, Irene; Latorre-Pellicer, Ana; Acín-Pérez, Rebeca; Martín-Cófreces, Noa; Jaso-Tamame, Ángel Luis; Iborra, Salvador; Jorge, Inmaculada; González-Aseguinolaza, Gloria; Garaude, Johan; Vicente-Manzanares, Miguel; Enríquez, José Antonio; Mittelbrum Herrero, María; Sánchez Madrid, Francisco
2018-07-09 -
Similarities and differences in extracellular vesicle profiles between ischaemic stroke and myocardial infarction
Otero-Ortega, Laura; Alonso-López, Elisa; Pérez-Mato, María; Laso-García, Fernando; Frutos, Mari Carmen Gómez De; Diekhorst, Luke; García-Bermejo, María Laura; Conde-Moreno, Elisa; Fuentes Gimeno, Blanca Eulalia; de Leciñana, María Alonso; Armada, Eduardo; Buiza-Palomino, Lorena; Díez Tejedor, Exuperio; Gutiérrez-Fernández, María
2021-12-24