dc.contributor.author | Keller, Laetitia | |
dc.contributor.author | Pijnenburg, Luc | |
dc.contributor.author | Idoux-Gillet, Ysia | |
dc.contributor.author | Bornert, Fabien | |
dc.contributor.author | Benameur, Laila | |
dc.contributor.author | Tabrizian, Maryam | |
dc.contributor.author | Auvray, Pierrick | |
dc.contributor.author | Rosset, Philippe | |
dc.contributor.author | Gonzalo-Daganzo, Rosa María | |
dc.contributor.author | Gómez Barrena, Enrique | |
dc.contributor.author | Gentile, Luca | |
dc.contributor.author | Benkirane-Jessel, Nadia | |
dc.contributor.other | UAM. Departamento de Cirugía | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | es_ES |
dc.date.accessioned | 2020-06-01T09:43:31Z | |
dc.date.available | 2020-06-01T09:43:31Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Nature Communications 10.1 (2019): 1-10 | en_US |
dc.identifier.issn | 2041-1723 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/691177 | |
dc.description.abstract | The extended life expectancy and the raise of accidental trauma call for an increase of
osteoarticular surgical procedures. Arthroplasty, the main clinical option to treat osteoarticular
lesions, has limitations and drawbacks. In this manuscript, we test the preclinical safety
of the innovative implant ARTiCAR for the treatment of osteoarticular lesions. Thanks to
the combination of two advanced therapy medicinal products, a polymeric nanofibrous bone
wound dressing and bone marrow-derived mesenchymal stem cells, the ARTiCAR promotes
both subchondral bone and cartilage regeneration. In this work, the ARTiCAR shows 1) the
feasibility in treating osteochondral defects in a large animal model, 2) the possibility to
monitor non-invasively the healing process and 3) the overall safety in two animal models
under GLP preclinical standards. Our data indicate the preclinical safety of ARTiCAR
according to the international regulatory guidelines; the ARTiCAR could therefore undergo
phase I clinical trial. | en_US |
dc.description.sponsorship | This work was supported by the ARTiCAR ANR grant (Agence Nationale de la
Recherche) and by SATT (Société d’Accélération du Transfert de Technologies) Conectus
Alsace. Authors are thankful to “Faculté de Chirurgie Dentaire de Strasbourg” for
the financial support. | en_US |
dc.format.extent | 10 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Nature Research (part of Springer Nature) | en_US |
dc.relation.ispartof | Nature Communications | en_US |
dc.rights | © The Author(s) 2019 | en_US |
dc.subject.other | Arthroplasty | en_US |
dc.subject.other | Osteoarticular lesions | en_US |
dc.subject.other | Wound dressing | en_US |
dc.subject.other | BMP2 | en_US |
dc.subject.other | Clinical trials | en_US |
dc.title | Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-019-10165-5 | es_ES |
dc.identifier.doi | 10.1038/s41467-019-10165-5 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationissue | 1 | es_ES |
dc.identifier.publicationlastpage | 10 | es_ES |
dc.identifier.publicationvolume | 10 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Gómez Barrena, Enrique (259841) | |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | |